Nitrofurantoin Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 67-20-9 |
| Product name | Nitrofurantoin |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Nitrofurantoin
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Nitrofurantoin Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Nitrofurantoin
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Antibacterial agent for treating lower urinary tract infections (e.g., acute cystitis, acute exacerbations of chronic cystitis) caused by susceptible bacteria | Administered orally; absorbed via the gastrointestinal tract and concentrated in urine, where it inhibits bacterial DNA, RNA, and protein synthesis by interfering with enzymatic systems (e.g., acetyl-CoA, nitroreductase); requires acidic urine for optimal activity—often co-administered with vitamin C to acidify urine |
| Pharmaceuticals | Long-term, low-dose maintenance therapy to prevent recurrent urinary tract infections | Single oral dose of 50–100 mg administered at bedtime daily, leveraging sustained urinary antibacterial concentrations for prophylaxis while minimizing rapid resistance development |
| Pharmaceuticals | Adjunctive treatment of bacterial cystitis in companion animals (e.g., dogs, cats) in veterinary clinical practice | Dosed according to body weight (typically 2–5 mg/kg, administered two to four times daily); renal function must be closely monitored due to interspecies metabolic differences that increase risk of toxic accumulation |
Manufacturing Quality Control of Nitrofurantoin
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of furazolidone and compare it with the standard spectrum to confirm whether its characteristic peaks are consistent. |
| Ultraviolet-Visible Spectrophotometry (UV-Vis) | Use the characteristic absorption of furazolidone at a specific wavelength (e.g., about 375 nm) for qualitative identification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 chromatographic column with an appropriate mobile phase (such as methanol-water or acetonitrile-buffer system) for separation, and detect using a UV detector at approximately 375 nm. Quantification is performed by external or internal standard methods. |
| Ultraviolet-Visible Spectrophotometry (UV-Vis) | Determine the absorbance at the maximum absorption wavelength, calculate the content based on the Lambert-Beer law, suitable for rapid determination of high-purity samples. | |
| Related Substances (Impurities) Test | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution programs to separate the main component from potential degradation products or synthetic impurities (such as 5-nitrofuran derivatives). Impurity limits are controlled using peak area normalization or reference substance methods. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Constant Pressure Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, measure the mass loss to evaluate the water and volatile matter content. |
| Residue on Ignition | Gravimetric Method | Weigh the inorganic residue after incinerating the sample at a high temperature (typically 700–800°C), used to control inorganic impurities. |
| Dissolution (Formulation) | Dissolution Test Method (Paddle or Basket Method) | Simulate the in vivo environment and determine the dissolution amount of furazolidone tablets or capsules in a defined medium (e.g., pH 6.8 phosphate buffer) over a certain period of time to evaluate formulation release performance. |
| pH Value (Solution) | pH Meter Measurement Method | Prepare a solution of furazolidone at a specified concentration and measure its acidity or alkalinity using a calibrated pH meter to ensure compliance with pharmacopoeia requirements. |
Technical Specifications of Nitrofurantoin
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 102°C - 106°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Nitrofurantoin
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Nitrofurantoin
Packaging of Nitrofurantoin
Industrial Nitrofurantoin Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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