China Factory Direct
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| CAS number | 694499-26-8 |
| Product name | 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing targeted anticancer drugs | Organic synthesis reactions, such as coupling and alkylation reactions |
| Chemical Research | Advanced organic synthesis reagent | Used to construct complex aromatic amine structures as functionalized molecular scaffolds |
| Biopharmaceuticals | Synthetic precursor for antitumor candidate compounds | Introduction of trifluoromethyl and piperazinyl groups via multistep synthesis |
| Materials Science | Intermediate for functional organic materials | Used in the preparation of organic semiconductors or fluorescent probes with specific electronic properties |
| Detection Item | Common Detection Methods | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyze hydrogen, carbon, and fluorine atoms' chemical environments using 1H NMR, 13C NMR, and/or 19F NMR to confirm molecular framework and substituent positions. |
| Infrared Spectroscopy (IR) | Identify characteristic functional group absorption peaks (e.g., -NH2, -CF3, aromatic rings), assisting in structural verification. | |
| Mass Spectrometry (MS) | Use ESI-MS or EI-MS to determine molecular ion peaks and fragment ions, confirming molecular weight and cleavage pathways to support structural identification. | |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Use a C18 reverse-phase column with a UV detector (e.g., 254 nm) to quantitatively determine the purity of the main component via retention time and area normalization. |
| Ultra-Performance Liquid Chromatography (UPLC) | Improve separation efficiency and speed, suitable for rapid purity assessment and trace impurity analysis. | |
| Related Substances/Impurity Detection | HPLC-UV / UPLC-UV | Optimize gradient elution conditions to separate and quantify process-related impurities, degradation products, etc., and set impurity limit standards. |
| LC-MS (Liquid Chromatography-Mass Spectrometry Coupling) | Qualitatively analyze unknown impurities by combining mass spectrometry data to infer structures, enhancing impurity identification capability. | |
| Residual Solvents | Gas Chromatography (GC-FID / GC-MS) | Use headspace injection or direct injection to detect residual organic solvents (e.g., dichloromethane, methanol, acetonitrile) from synthesis. |
| Water Content | Karl Fischer Titration | Use volumetric or coulometric methods to precisely determine water content in the sample, ensuring compliance with pharmacopoeia or process requirements. |
| Heavy Metals/Elemental Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | High-sensitivity detection of trace metal elements (e.g., Pd, Cu, Ni) from catalyst residues, compliant with ICH Q3D requirements. |
| Crystalline Form/Solid-State Properties | X-ray Powder Diffraction (XRPD) | Analyze crystal structure characteristic peaks to confirm whether multiple polymorphic forms exist, ensuring batch consistency. |
| Differential Scanning Calorimetry (DSC) | Determine crystalline stability and phase transition temperature through melting point and thermal behavior. | |
| Content Determination | HPLC External Standard Method / Area Normalization Method | Establish a standard curve using a reference standard, accurately determining the content of the main component (typically 98.0–102.0%). |
| pH Value / Solution Clarity | pH Meter / Visual Turbidimetry | Prepare a solution of certain concentration, measure pH value; observe clarity to assess solubility and potential insoluble substances. |
| Charred Residue | High-Temperature Ashing Method | Heat the sample at high temperatures (e.g., 600–800°C), weigh the residual inorganic matter, and evaluate the total amount of inorganic salts or metal oxides. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Danger |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.