Ethyl 7-nitroindole-2-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6960-46-9 |
| Product name | Ethyl 7-nitroindole-2-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ethyl 7-nitroindole-2-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ethyl 7-nitroindole-2-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ethyl 7-nitroindole-2-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing antiviral and antitumor active compounds (e.g., indole-based kinase inhibitors) | Used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki or Heck reactions) in inert solvents (e.g., DMF or THF), or applied in multi-step transformations—including hydrolysis, reduction, and cyclization—to construct the target molecular scaffold |
| Organic Synthesis | Heterocyclic functionalization building block featuring dual modifiable sites: nitro and ester groups | The nitro group can be selectively reduced to an amino group for subsequent diazotization or acylation; the ester group can be saponified to a carboxylic acid or aminolyzed to an amide, enabling structural diversification |
Manufacturing Quality Control of Ethyl 7-nitroindole-2-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally similar impurities (e.g., unreacted nitroindole, hydrolysis products) using gradient HPLC-UV with system suitability criteria. |
| Residual Solvents | GC-FID | Measures residual ethyl acetate, ethanol, toluene, or DMF by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generated electrochemically in pyridine-free reagent. |
| Heavy Metals | ICP-MS | Quantifies Pb, Cd, Hg, As, and other regulated metals after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction and filtration. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or foreign matter against established reference standards under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Measures volatile content by weight loss after drying at 60 C under vacuum for 2 hours per Ph. Eur. 2.2.32. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid content by titration with standardized NaOH solution using phenolphthalein indicator. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content after incineration at 600 C for 1 hour, followed by weighing of residual residue. |
| Specific Optical Rotation | Polarimetry | Measures chiral purity (if applicable) using sodium D-line light at specified concentration and path length; reported as degrees per g/mL. |
Technical Specifications of Ethyl 7-nitroindole-2-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148-152°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ethyl 7-nitroindole-2-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Ethyl 7-nitroindole-2-carboxylate
Safety Information of Ethyl 7-nitroindole-2-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Ethyl 7-nitroindole-2-carboxylate
Industrial Ethyl 7-nitroindole-2-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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