5-Fluoronicotinamide Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 70-58-6 |
| Product name | 5-Fluoronicotinamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 5-Fluoronicotinamide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Fluoronicotinamide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Fluoronicotinamide
| Industry | Application | Process |
|---|---|---|
| Pesticides | Herbicide intermediate (e.g., for synthesis of flumioxazin) | Prepared via multi-step reactions—including substitution, hydrolysis, and condensation—with halogenated arenes such as 2-chloro-5-(trifluoromethyl)pyridine |
| Pharmaceuticals | Antitumor drug intermediate (e.g., structural modification unit in EGFR inhibitors) | Used as a fluorinated heterocyclic building block in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) or nucleophilic substitution to introduce fluorinated motifs into drug scaffolds |
| Organic Synthesis | Key building block for synthesizing fluorinated fine chemicals | Employed to construct fluorinated nicotinamide derivatives, followed by functional group transformations—including bromination, nitration, reduction, or N-alkylation—to produce functional materials or analytical standards |
Manufacturing Quality Control of 5-Fluoronicotinamide
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 220-254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion, using isotopic detection for high sensitivity. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified against chloride standard calibration curve. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 600-700 C followed by weighing of non-volatile residue to assess inorganic impurity load. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference value (139-141 C). |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light by chiral molecules in solution; used to confirm enantiomeric integrity (if applicable) and absence of racemization. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie theory to derive D10, D50, D90 values relevant to handling and formulation performance. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | pH measurement of 1% w/v suspension in purified water using calibrated pH electrode to assess acidic/basic impurities. |
| Microbial Limits | Membrane Filtration | Quantitative recovery and enumeration of aerobic bacteria, yeasts, and molds per USP <61> or Ph. Eur. 2.6.12. |
Technical Specifications of 5-Fluoronicotinamide
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 142-146°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 5-Fluoronicotinamide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 5-Fluoronicotinamide
Industrial 5-Fluoronicotinamide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply