D-1-N-BOC-PROLINAMIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 70138-72-6 |
| Product name | D-1-N-BOC-PROLINAMIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for D-1-N-BOC-PROLINAMIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk D-1-N-BOC-PROLINAMIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of D-1-N-BOC-PROLINAMIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for synthesis of antiviral agents and protease inhibitors | Used in solid-phase or solution-phase peptide synthesis to couple with amino acid derivatives, constructing bioactive molecules containing a pyrrolidine scaffold |
| Pharmaceuticals | Intermediate for preparing HIV protease inhibitors (e.g., atazanavir analogues) | Reacted with carboxylic acid activation reagents (e.g., HATU, EDC) in organic solvents to form amide bonds, followed by deprotection |
| Pharmaceuticals | Chiral building block for synthesizing NS3/4A protease inhibitors | Undergoes stereoselective reduction or asymmetric catalytic reactions to introduce amino and tert-butyl ester groups, ensuring configurational purity |
| Chemical R&D | Building block for nitrogen-containing heterocyclic drug candidate libraries | Applied as a multifunctional unit bearing both amino and ester functionalities in Mitsunobu reactions, reductive aminations, or cyclizations |
Manufacturing Quality Control of D-1-N-BOC-PROLINAMIDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, calibrated against reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase and UV detection to resolve (2R) from (2S) enantiomer. |
| Residual Solvents | GC-FID | Identification and quantification of common solvents (e.g., ethyl acetate, heptane, MTBE) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content in the sample. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion and plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantitative analysis of palladium catalyst residue following microwave-assisted acid digestion and optical emission spectroscopy. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of visible particulates or discoloration under controlled white light. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 deg C using sodium D-line (589 nm) to confirm chiral integrity. |
| Loss on Drying | Gravimetric Thermogravimetry | Weight loss measurement after drying at 60 deg C under vacuum for 2 hours, indicating volatile impurities and moisture. |
| Related Substances | HPLC-UV (Forced Degradation) | Detection and quantification of structurally related impurities (e.g., deprotected acid, hydrolyzed amide) using stability-indicating gradient HPLC. |
| Residual tert-Butyl Carbamate | GC-MS | Targeted identification and quantification of Boc group cleavage byproduct via gas chromatography coupled with mass spectrometry. |
Technical Specifications of D-1-N-BOC-PROLINAMIDE
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +38.0 to +42.0 deg (c=0.5, EtOH) |
| Melting Point | 78.0 to 82.0 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of D-1-N-BOC-PROLINAMIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of D-1-N-BOC-PROLINAMIDE
Packaging of D-1-N-BOC-PROLINAMIDE
Industrial D-1-N-BOC-PROLINAMIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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