3-Oxo-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Ethyl Ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71233-25-5 |
| Product name | 3-Oxo-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Ethyl Ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 71233-25-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 71233-25-5 Supplier from China
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Industrial Applications of 71233-25-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Critical intermediate for synthesizing piperidine-containing drug molecules (e.g., NK1 receptor antagonists, DPP-4 inhibitors for diabetes treatment) | Used as a chiral building block in multi-step total synthesis; the piperidinone scaffold is introduced via reduction, Boc deprotection, and coupling reactions |
| Organic Synthesis | Boc-protected piperidinone derivative for constructing nitrogen-containing heterocycles and functionalized side chains | Substituents are introduced at the α-position adjacent to the 3-carbonyl group via LDA- or NaH-mediated alkylation/acylation; subsequent selective Boc deprotection enables downstream transformations |
Manufacturing Quality Control of 71233-25-5
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV/DAD | Separation and detection of structurally related impurities (e.g., de-Boc, hydrolyzed, or diastereomeric impurities) using gradient HPLC with diode-array detection. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., ethyl acetate, toluene, DMF) by gas chromatography with flame ionization detection against internal/external standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content based on the stoichiometric reaction of iodine with water in anhydrous methanol/pyridine medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Optical Purity (Enantiomeric Excess) | Chiral HPLC | Separation and quantification of enantiomers using a chiral stationary phase (e.g., Chiralpak AD-H), with UV detection and comparison to racemic and enantiopure references. |
| Residual Palladium | ICP-OES | Quantification of residual Pd catalyst after microwave-assisted digestion, using inductively coupled plasma optical emission spectrometry at characteristic wavelengths (e.g., 247.6 nm). |
| Acid Value | Potentiometric Titration | Determination of free carboxylic acid groups via titration with standardized NaOH solution, using a pH electrode for endpoint detection. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic residue after controlled high-temperature ashing (700–800 °C), expressed as weight percent of original sample. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory applied to laser diffraction measurements under controlled dispersion. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change in a capillary tube under controlled heating rate (e.g., 1 °C/min). |
Technical Specifications of 71233-25-5
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78°C to 82°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15.0° to -19.0° (c=1, in CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 71233-25-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 71233-25-5
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Industrial 71233-25-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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