5-bromo-6-chloronicotinonitrile Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71702-01-7 |
| Product name | 5-bromo-6-chloronicotinonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-bromo-6-chloronicotinonitrile
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-bromo-6-chloronicotinonitrile Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-bromo-6-chloronicotinonitrile
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a key structural scaffold for synthesizing pyridine-derived drugs, such as P2Y12 receptor antagonists (e.g., cangrelor) and their active metabolites. |
| Pharmaceutical Chemicals | Active Pharmaceutical Ingredient (API) Synthesis | Leverages the reactivity of its halogen substituents to prepare nicotinic acid or nicotinamide derivatives via nitrile hydrolysis. |
| Agrochemicals | Agrochemical Intermediates | Applied in synthesizing pyridine-ring-containing insecticides or herbicides; coupling reactions introduce additional functional groups to enhance biological activity. |
| Organic Synthesis | Specialty Chemicals Synthesis | Exploits the differential reactivity of bromo- and chloro-substituents to achieve regioselective functionalization for constructing complex organic molecules. |
Manufacturing Quality Control of 5-bromo-6-chloronicotinonitrile
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~220–254 nm, comparing peak area against a certified reference standard. |
| Residual Solvents | GC-FID | Separation and quantification of volatile organic solvents (e.g., dichloromethane, toluene) using capillary GC with flame ionization detection and external calibration. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element trace metal quantification after acid digestion, based on mass spectrometric detection of elemental isotopes with high sensitivity and selectivity. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample water in anhydrous methanol-based electrolyte. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Determination of inorganic ash content by ignition at 700–800 °C followed by precise weighing of residual inorganic matter. |
| Chloride Impurities (e.g., Cl⁻) | Ion Chromatography (IC) | Separation and quantification of ionic chloride using anion-exchange column with suppressed conductivity detection and external calibration. |
| Related Substances (Impurity Profile) | HPLC-UV/DAD | Identification and quantification of structurally related impurities (e.g., bromo/chloro isomers, hydrolysis products) using gradient HPLC with diode-array detection. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change under controlled heating rate (e.g., 1 °C/min) per pharmacopeial standards. |
| Particle Size Distribution | Laser Diffraction | Size analysis based on angular scattering intensity of laser light passing through dispersed particles in air or liquid medium. |
| Bulk Density | ASTM D1895 (Method A) | Measurement of mass per unit volume of freely settled powder in a calibrated cylinder, reported as g/mL. |
| Organic Volatile Impurities (e.g., benzene, chloroform) | GC-MS | Targeted and non-targeted screening/quantification using gas chromatography coupled to mass spectrometry with selected ion monitoring (SIM). |
Technical Specifications of 5-bromo-6-chloronicotinonitrile
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78-82°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-bromo-6-chloronicotinonitrile
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-bromo-6-chloronicotinonitrile
Safety Information of 5-bromo-6-chloronicotinonitrile
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-bromo-6-chloronicotinonitrile
Industrial 5-bromo-6-chloronicotinonitrile Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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