N-Cbz-2-Amino-1,3-propanediol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71811-26-2 |
| Product name | N-Cbz-2-Amino-1,3-propanediol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Cbz-2-Amino-1,3-propanediol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Cbz-2-Amino-1,3-propanediol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Cbz-2-Amino-1,3-propanediol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral intermediate for synthesizing antiviral agents (e.g., HIV protease inhibitors) | Condensation with aldehydes/ketones under basic conditions, or preparation of the target API via chiral synthesis processes such as asymmetric reduction or enzymatic resolution |
| Organic Synthesis | Bifunctional protected building block containing hydroxyl and amino groups, used in peptide and heterocyclic compound synthesis | CBZ-protected amino group participates in amide coupling (e.g., activated by EDC/HOBt); primary hydroxyl group undergoes selective derivatization (e.g., mesylation or halogenation) followed by nucleophilic substitution |
| New Materials | Crosslinker or chain terminator for producing biodegradable polyurethanes or epoxy resins | Deprotection of the CBZ group releases the primary amine, which undergoes addition reactions with isocyanate or epoxy groups to control polymer molecular weight and crosslink density |
Manufacturing Quality Control of N-Cbz-2-Amino-1,3-propanediol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 200–220 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., N-CBZ-serinol degradation products, residual solvents, isomers) using gradient HPLC-UV with a C18 column. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration based on the reaction of iodine with water in anhydrous methanol/pyridine medium; measures trace moisture by coulometric iodine generation. |
| Residual Solvents (e.g., MeOH, EtOAc, DCM) | GC-FID | Gas chromatographic separation followed by flame ionization detection; quantifies volatile organic solvents using internal standard calibration. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantitative analysis via inductively coupled plasma mass spectrometry after acid digestion; offers sub-ppt detection limits. |
| Chloride Impurity | Ion Chromatography (IC) | Anion exchange separation with suppressed conductivity detection; quantifies chloride ions based on retention time and peak area calibration. |
| Optical Rotation | [α]D | Measurement of specific rotation using a digital polarimeter at 589 nm (Na-D line); verifies chiral integrity and enantiomeric purity. |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic ash content by high-temperature incineration (500–600 °C) followed by precise weighing of residual residue. |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Direct measurement using calibrated glass electrode in aqueous suspension; reflects acidic/basic impurities and salt formation. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition analysis via controlled heating; confirms identity and crystallinity by comparison to literature value (75–78 °C). |
Technical Specifications of N-Cbz-2-Amino-1,3-propanediol
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 72-76°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Optical Rotation | -15.0 to -19.0° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Cbz-2-Amino-1,3-propanediol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Cbz-2-Amino-1,3-propanediol
Safety Information of N-Cbz-2-Amino-1,3-propanediol
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Cbz-2-Amino-1,3-propanediol
Industrial N-Cbz-2-Amino-1,3-propanediol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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