Fmoc-L-glutamic acid 5-tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71989-18-9 |
| Product name | Fmoc-L-glutamic acid 5-tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-L-glutamic acid 5-tert-butyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-L-glutamic acid 5-tert-butyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-L-glutamic acid 5-tert-butyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a protected amino acid monomer in peptide synthesis to construct therapeutic peptides containing glutamic acid residues | Applied in solid-phase peptide synthesis (SPPS) using the Fmoc strategy for α-amino protection and tert-butyl groups for side-chain carboxyl protection |
| Biotechnology | Used to synthesize custom peptides for antibody–drug conjugate (ADC), vaccine, and diagnostic reagent development | Employed in automated peptide synthesizers for stepwise sequence assembly, followed by deprotection with trifluoroacetic acid (TFA) and purification |
| Research | Used in protein structure–function studies, enzyme substrate design, and cell-penetrating peptide construction | Applied in manual or automated solid-phase synthesis, with product verification via HPLC and mass spectrometry |
Manufacturing Quality Control of Fmoc-L-glutamic acid 5-tert-butyl ester
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state under natural light or standard illumination; it should appear as a white to off-white powder with no visible impurities. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Utilize a reversed-phase C18 column with UV detection (typically at 265 nm or 220 nm). The main component content is calculated based on retention time and peak area. Purity is generally required to be ≥98% or ≥99%. |
| Chiral Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use a chiral column to separate L- and D-isomers, assessing enantiomeric excess (ee value) to ensure minimal D-isomer impurities. Typically requires ee ≥99%. |
| Moisture Content | Karl Fischer Titration | Determine water content using coulometric or volumetric Karl Fischer methods. Control moisture within a specified range (e.g., ≤0.5%) to prevent hydrolysis or degradation during storage. |
| Residual Solvents | Gas Chromatography (GC) | Test for residual organic solvents (e.g., dichloromethane, DMF, ethyl acetate) from synthesis processes. Limits are set according to ICH guidelines. |
| Melting Point | Melting Point Determination by Melting Point Apparatus | Determine the melting temperature range using an automatic melting point instrument. For Fmoc-Glu(OtBu)-OH, the typical melting point range is 85–95°C. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Confirm functional groups via characteristic absorption peaks, such as carbonyl (~1710 cm⁻¹, ~1730 cm⁻¹), aromatic rings (~1500–1600 cm⁻¹), and specific peaks of the Fmoc group, used for structural confirmation. |
| Nuclear Magnetic Resonance (NMR) | ¹H NMR and ¹³C NMR | Use deuterated DMSO or CDCl₃ as solvent. Confirm molecular structure and purity through chemical shifts, integration, and splitting patterns. This is a key method for structural verification. |
| UV Absorption | UV-Visible Spectrophotometry | Determine maximum absorption wavelength (λmax ≈ 265 nm) in methanol or acetonitrile, used for quantitative support or confirmation of the presence of the Fmoc group. |
| Residue on Ignition / Sulfate Ash | Gravimetric Method | After high-temperature incineration, weigh the residue to assess inorganic impurities. Typically requires ≤0.1%. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect toxic metal residues such as lead, mercury, cadmium, and arsenic. Must comply with pharmacopoeial or client-specified standards (e.g., ≤10 ppm). |
Technical Specifications of Fmoc-L-glutamic acid 5-tert-butyl ester
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -10.0 to -7.0 deg (c=1, in DMF) |
| Melting Point | 135 to 140 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-L-glutamic acid 5-tert-butyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-L-glutamic acid 5-tert-butyl ester
Safety Information of Fmoc-L-glutamic acid 5-tert-butyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-L-glutamic acid 5-tert-butyl ester
Industrial Fmoc-L-glutamic acid 5-tert-butyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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