FMOC-O-tert-Butyl-L-serine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71989-33-8 |
| Product name | FMOC-O-tert-Butyl-L-serine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for FMOC-O-tert-Butyl-L-serine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMOC-O-tert-Butyl-L-serine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMOC-O-tert-Butyl-L-serine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of peptide-based drugs, used to construct serine-containing, protected amino acid building blocks | Used as an Fmoc-protected serine derivative in solid-phase peptide synthesis (SPPS) for coupling reactions |
| Biotechnology | Synthesis of custom peptides for protein engineering and functional studies | Peptide chain elongation under the Fmoc/tBu strategy, with the hydroxyl group protected by tert-butyl and the α-amino group protected by Fmoc |
| Chemical Research | Chiral building block for developing novel organic molecules or probes | Participates in asymmetric synthesis or labeling reactions following deprotection and functional group transformation |
Manufacturing Quality Control of FMOC-O-tert-Butyl-L-serine
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection + Physical Property Testing | Observe the sample as white to off-white crystalline powder, check for clumping, discoloration, or foreign matter, and determine the melting point range (typically 95–102 °C). |
| High-Performance Liquid Chromatography (HPLC) | Compare the retention time with that of the reference standard to confirm the identity of the compound. Commonly uses a C18 column with mobile phase of acetonitrile/water (containing 0.1% TFA). | |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Confirm the structure using characteristic proton signals (e.g., aromatic protons of Fmoc at δ 7.2–7.4 ppm, isopropyl single peak at δ 1.4–1.5 ppm, serine CH₂ at δ 3.7–3.9 ppm). | |
| Content Determination (Purity) | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Determine the main peak area percentage using external standard or area normalization method. Typically requires purity ≥98.0%, with detection wavelength at 260–280 nm (Fmoc absorption). |
| Residual Solvents | Gas Chromatography (GC) | Detect common solvents such as methanol, ethanol, ethyl acetate, and dichloromethane according to ICH Q3C guidelines. Use DB-624 column and FID detector. |
| Moisture Content | Karl Fischer Titration | Determine moisture content using either volumetric or coulometric method. Typically requires ≤0.5% (w/w), ensuring stability and crystallinity. |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography with UV/MS Detection (HPLC-UV/MS) | Use gradient elution to separate degradation products (e.g., de-Fmoc compounds, hydrolysis products, oxidation products). Detection limit typically ≤0.1%. Mass spectrometry (LC-MS) may be used for structural identification when necessary. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detect heavy metals such as lead, cadmium, mercury, and arsenic according to pharmacopeia methods (e.g., USP <231>). Limit values are typically ≤10 ppm. |
| Inorganic Impurities (Chlorides, Sulfates, etc.) | Colorimetric Method or Ion Chromatography | Chlorides are detected by silver nitrate turbidity method; sulfates are detected by barium chloride turbidity method. Alternatively, use ion chromatography to detect anion residues, complying with pharmacopeia limits. |
| Solubility | Physical Dissolution Experiment | Determine the solubility behavior in common solvents (e.g., DCM, DMF, ethanol, water), confirming it meets process requirements (e.g., soluble in DMF, slightly soluble in water). |
| Enantiomeric Purity (Chiral Purity) | Chiral HPLC or LC-MS | Use chiral stationary phase columns (e.g., Chiralpak AD/AS) to separate D/L enantiomers, ensuring L-enantiomer purity ≥99.0%. |
| Ultraviolet Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Determine the molar absorptivity (ε) at 260–280 nm in acetonitrile or DMF, used for quantitative verification (characteristic absorption of Fmoc group). |
Technical Specifications of FMOC-O-tert-Butyl-L-serine
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +22.0 to +27.0 (c=1, in DMF) |
| Melting Point | 145 to 150 °C |
| Identification (NMR) | Conforms to structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of FMOC-O-tert-Butyl-L-serine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of FMOC-O-tert-Butyl-L-serine
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Industrial FMOC-O-tert-Butyl-L-serine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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