FMOC-O-tert-Butyl-L-threonine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 71989-35-0 |
| Product name | FMOC-O-tert-Butyl-L-threonine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for FMOC-O-tert-Butyl-L-threonine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMOC-O-tert-Butyl-L-threonine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMOC-O-tert-Butyl-L-threonine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Monomer for synthesizing peptide-based drugs | Used in solid-phase or solution-phase peptide synthesis with Fmoc protection strategy |
| Biotechnology | Peptide synthesis for research | Applied as protected amino acid derivatives for custom peptide synthesis |
| Medical Diagnostics | Development of labeled peptides | Employed in chemical conjugation reactions to construct functional peptide sequences |
| Chemical Industry | Intermediate for organic synthesis | Participates in condensation, substitution, and other reactions under inert atmosphere |
Manufacturing Quality Control of FMOC-O-tert-Butyl-L-threonine
| Detection Item | Common Detection Method | Method Overview |
|---|---|---|
| Chemical Purity | High-Performance Liquid Chromatography (HPLC) | Using a C18 reverse-phase chromatography column, with a gradient elution of water-acetonitrile (containing 0.1% TFA), UV detection (210–220 nm), calculating the main peak area ratio to assess impurity content. |
| Content Determination (Purity Quantification) | HPLC Area Normalization Method or External Standard Method | Using a standard substance of known purity to establish a standard curve, quantifying the content of Fmoc-O-tert-butyl-L-threonine in the sample by the main peak area (typically ≥98%). |
| Melting Point | Melting Point Instrument Method | Determining the melting range using a capillary method or an automatic melting point apparatus, with a typical melting point range of 108–112°C, used to judge crystal purity and consistency. |
| Moisture Content | Karl Fischer Titration | Using an iodine-sulfur dioxide-pyridine-methanol system for quantitative reaction with water, determining trace moisture content in the sample (typically ≤0.5%) via electrochemical or volumetric methods. |
| Residual Solvents | Gas Chromatography (GC) | Using a DB-624 or HP-INNOWAX chromatography column with headspace injection, detecting residual solvents such as ethanol, ethyl acetate, and dichloromethane, complying with ICH Q3C standards. |
| Optical Rotation | Automatic Polarimeter Method | Preparing a solution of the sample in methanol or DMF at a certain concentration (e.g., 1%), measuring the specific optical rotation [α]D²⁰ at 20°C, with a theoretical value of approximately +10° to +14°, used to confirm chiral purity. |
| Chloride/Ionic Impurities | Ion Chromatography (IC) or Silver Nitrate Titration | Detecting chloride and other halide impurities using ion chromatography, or determining total halide content via silver nitrate precipitation titration (typically ≤50 ppm). |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, using AAS or ICP-MS to determine the content of heavy metals such as lead, cadmium, mercury, and arsenic, complying with pharmacopoeia standards (e.g., ≤10 ppm). |
| Fmoc Group Integrity | UV-Visible Spectrophotometry (UV-Vis) | Measuring the characteristic absorption peak of the Fmoc group at 260–270 nm, verifying whether the Fmoc protecting group is intact and excluding deprotection byproducts. |
| Amino Acid Chirality Purity (Enantiomers) | Chiral HPLC or Derivatized HPLC | Using a chiral column (e.g., Chiralpak AD/AS) or chiral reagents (e.g., Marfey’s reagent) for derivatization followed by HPLC separation, confirming L-configuration purity (≥99% ee). |
| Nitrogen Content | Kjeldahl Method or Elemental Analysis (EA) | Determining total nitrogen content in the sample via combustion oxidation, comparing it with the theoretical value (C₁₉H₂₅NO₅, N% ≈7.2%) to verify molecular composition correctness. |
| Appearance and Solubility | Visual Inspection and Solubility Test | Checking for white to off-white crystalline powder, soluble in DMF and DMSO, slightly soluble in ethanol, and insoluble in water, complying with appearance and solubility standards. |
Technical Specifications of FMOC-O-tert-Butyl-L-threonine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Optical Rotation | +14.0 to +17.0° (c=1, in DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of FMOC-O-tert-Butyl-L-threonine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of FMOC-O-tert-Butyl-L-threonine
Safety Information of FMOC-O-tert-Butyl-L-threonine
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of FMOC-O-tert-Butyl-L-threonine
Industrial FMOC-O-tert-Butyl-L-threonine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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