4,6-Dichloroquinazoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 7253-22-7 |
| Product name | 4,6-Dichloroquinazoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4,6-Dichloroquinazoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4,6-Dichloroquinazoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4,6-Dichloroquinazoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Intermediate for antitumor drugs | Serves as a key scaffold structure in the synthesis of epidermal growth factor receptor (EGFR) inhibitors containing a quinazoline moiety, via nucleophilic substitution reactions (e.g., with amines). |
| Pharmaceutical Chemicals | Intermediate for protein kinase inhibitors | Leverages the reactivity of substituents at the 2-, 4-, and 6-positions to construct 4-aminoquinazoline derivatives for treating diseases such as non-small cell lung cancer. |
| Agrochemicals | Building block for pesticide molecular design | Used to synthesize novel quinazoline-based compounds exhibiting insecticidal or fungicidal activity. |
| Organic Synthesis | Raw material for specialty chemical synthesis | Acts as an electrophilic reagent to introduce the quinazoline ring system in C–N coupling reactions for functional material preparation. |
Manufacturing Quality Control of 4,6-Dichloroquinazoline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or UPLC-UV | Separation and quantification of structurally related impurities (e.g., mono-chloro analogs, quinazolinone derivatives) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., dichloromethane, toluene, DMF) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS or ICP-OES | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, based on USP <232>/<233> or Ph. Eur. 2.4.20. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content via iodine generation and stoichiometric reaction with water. |
| Chloride Content | Potentiometric Titration with AgNO₃ | Titration with silver nitrate using a silver indicator electrode to determine total inorganic chloride impurities. |
| Melting Point | Capillary Melting Point Apparatus | Thermal determination of solid–liquid transition range using calibrated capillary apparatus per Ph. Eur. 2.2.14. |
| Appearance & Color | Visual Inspection / APHA Color Scale | Subjective assessment of crystallinity and color intensity against platinum-cobalt standards. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Determination of inorganic residue after controlled ashing at 700–800 °C per USP <281>. |
Technical Specifications of 4,6-Dichloroquinazoline
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 218–222°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.3% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4,6-Dichloroquinazoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4,6-Dichloroquinazoline
Packaging of 4,6-Dichloroquinazoline
Industrial 4,6-Dichloroquinazoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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