HEPES Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 7365-45-9 |
| Product name | HEPES |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for HEPES
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk HEPES Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of HEPES
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Used as a biological buffer in cell culture, enzymatic reactions, and protein purification | Maintains stable buffering capacity within pH 6.8–8.2; commonly applied in in vitro diagnostic reagents and biological assay systems |
| In Vitro Diagnostics | Employed in clinical test kits to stabilize pH and ensure assay accuracy | Formulated as a component of HEPES buffer for immunoassays, clinical chemistry assays, and blood analysis systems |
| Pharmaceutical R&D | Utilized for drug solubilization, stability testing, and formulation development | Applied as a non-ionic buffer to enhance aqueous solubility and chemical stability of drug molecules |
| Medical Devices | Used for pH adjustment in certain extracorporeal circulation and dialysis solutions | Combined with saline or electrolyte solutions to maintain hemocompatible conditions |
| Personal Care | Applied as a pH adjuster in skin care products | Maintains skin compatibility in mild acidic to neutral formulations, improving product stability |
Manufacturing Quality Control of HEPES
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Take an appropriate amount of sample and place it on a white background. Observe its color and appearance under natural light or standard light sources. It should appear as a white to off-white crystalline powder. |
| Identification | Infrared Spectroscopy (IR) | Prepare a KBr pellet of the sample and measure its infrared absorption spectrum. Compare it with the reference spectrum of the standard substance. The main absorption peak positions should be consistent. |
| Identification | Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR) | Dissolve the sample in deuterated water (D₂O) or another suitable deuterated solvent, and measure the ¹H NMR spectrum. The characteristic chemical shift should match the standard spectrum. |
| pH Value | pH Meter Method | Prepare a solution of a certain concentration (e.g., 1% w/v) in water. Measure the pH value using a calibrated pH meter at a specified temperature (usually 25°C). The pH value should fall within the specified range (e.g., 2.8–3.2). |
| Content Determination | HPLC (High-Performance Liquid Chromatography) | Use a reverse-phase C18 column with a mobile phase consisting of phosphate buffer-ethanol, etc. Detect using a UV detector (e.g., 210 nm). Calculate the content of the main component using the external standard method, typically requiring ≥99.0%. |
| Content Determination | Acid-Base Titration | Dissolve the sample in water and titrate with a standard sodium hydroxide solution. Determine the endpoint using potentiometry or an indicator. Calculate the HEPES content. This method is suitable for rough quantification when there are no interfering impurities. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Atmospheric Drying | Dry the sample at 105°C until constant weight is reached. Calculate the moisture and volatile matter content based on the difference in mass before and after drying. Typically, this should be ≤0.5%. |
| Residual Ash | High-Temperature Incineration | Char the sample and incinerate it in a high-temperature furnace (700–800°C) until constant weight is achieved. Weigh the residual inorganic matter and calculate its mass. Typically, this should be ≤0.1%. |
| Heavy Metals | Thioacetamide Method (or ICP-MS) | Follow the pharmacopoeia method to process the sample, add thioacetamide for coloring, and determine by colorimetry. Alternatively, use Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for trace metal element quantification. Total heavy metals are usually required to be ≤10 ppm. |
| Chlorides | Silver Nitrate Turbidimetry | Acidify the sample solution with nitric acid and add silver nitrate. Compare the turbidity with that produced by a standard sodium chloride solution to control the level of chloride impurities. |
| Sulfates | Barium Chloride Turbidimetry | Acidify the sample solution with hydrochloric acid and add barium chloride. Compare the turbidity with that produced by a standard potassium sulfate solution to control sulfate impurities. |
| Related Substances (Impurities) | HPLC (High-Performance Liquid Chromatography) | Use gradient elution or isocratic conditions to separate and detect potential organic impurities (such as synthetic intermediates or degradation products). Individual impurities should typically be ≤0.1%, and total impurities ≤0.5%. |
| Moisture | Karl Fischer Titration | Determine the moisture content in the sample using either the volumetric or coulometric Karl Fischer reagent. This method provides precise measurement of water content, typically requiring ≤0.5%. |
Technical Specifications of HEPES
| Test Item | Specification |
|---|---|
| Appearance | White crystal powder |
| Assay | 99.0% ~ 101.0% |
| Loss on drying | ≤1.0% |
| pH(1% water solution) | 5.0 ~ 6.5 |
| Heavy metals as pb | ≤10 ppm |
| UV absorbance 260nm (1M water solution) | ≤0.1 |
| UV absorbance 280nm (1M water solution) | ≤0.07 |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of HEPES
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NMR Spectra of HEPES
Packaging of HEPES
Industrial HEPES Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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