3-Bromo-5-hydroxypyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 74115-13-2 |
| Product name | 3-Bromo-5-hydroxypyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-Bromo-5-hydroxypyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Bromo-5-hydroxypyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Bromo-5-hydroxypyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate in the synthesis of anticancer agents (e.g., EGFR inhibitors) | Brominated pyridine ring undergoes selective hydroxylation or hydroxyl protection/deprotection prior to coupling reactions |
| Agrochemical Intermediates | Used in the preparation of novel insecticides and fungicides (e.g., neonicotinoid derivatives) | Undergoes nucleophilic substitution with amines or thiols to construct the active molecular scaffold |
| Organic Synthesis | Multi-functional building block for constructing nitrogen-containing heterocyclic compounds | Aryl or alkenyl groups are introduced via transition-metal-catalyzed cross-coupling (e.g., Suzuki, Heck reactions) |
Manufacturing Quality Control of 3-Bromo-5-hydroxypyridine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and presence of visible impurities in the sample under natural light or standard illumination. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase column (e.g., C18) with water/organic solvent (e.g., methanol or acetonitrile) as the mobile phase. Detect purity of the main peak using a UV detector, and quantify via external standard or area normalization method. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Perform 1H NMR and 13C NMR analyses to confirm the chemical environments of hydrogen and carbon atoms are consistent with the target molecular structure. |
| Structural Confirmation | Mass Spectrometry (MS) | Use electrospray ionization (ESI) or electron ionization (EI) MS to detect the molecular ion peak ([M+H]+ or M·+) and verify the molecular weight. |
| Assay | HPLC External Standard Method | Construct a calibration curve using standard solutions of known concentrations; calculate the exact content of 3-bromo-5-hydroxypyridine based on sample peak area. |
| Residual Solvents | Gas Chromatography (GC) | Detect organic solvents possibly remaining from manufacturing (e.g., methanol, ethanol, dichloromethane) according to ICH guidelines, using an FID detector. |
| Moisture Content | Karl Fischer Titration | Measure water content based on the quantitative reaction of iodine with sulfur dioxide in the presence of pyridine and methanol; suitable for trace moisture determination. |
| Melting Point | Melting Point Apparatus | Determine the initial and final melting temperatures using an automated or capillary melting point apparatus to assess substance purity and consistency. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect residual heavy metal elements such as lead, cadmium, mercury, and arsenic, ensuring compliance with pharmacopeial or regulatory limits. |
| Related Substances (Impurities) | HPLC Method | Optimize chromatographic conditions to separate the main component from potential synthesis by-products or degradation impurities; evaluate the number and size of impurity peaks. |
Technical Specifications of 3-Bromo-5-hydroxypyridine
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 142–146 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-Bromo-5-hydroxypyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-Bromo-5-hydroxypyridine
Packaging of 3-Bromo-5-hydroxypyridine
Industrial 3-Bromo-5-hydroxypyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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