Methotrexate disodium salt Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 7413-34-5 |
| Product name | Methotrexate disodium salt |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methotrexate disodium salt
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methotrexate disodium salt Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methotrexate disodium salt
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for anticancer drugs | Used in the preparation of methotrexate formulations administered intravenously or orally to treat malignant tumors including leukemia, lymphoma, and breast cancer |
| Pharmaceuticals | Immunosuppressant | Applied in the treatment of autoimmune disorders such as rheumatoid arthritis and psoriasis to modulate immune system function |
| Life Sciences Research | Cell culture supplement | Employed as a selective reagent in cell culture for screening cells transfected with specific genes (e.g., DHFR gene amplification systems) |
| Pharmaceuticals | Ectopic pregnancy treatment | Administered via intramuscular injection to inhibit trophoblast cell proliferation for non-surgical management of early ectopic pregnancy |
Manufacturing Quality Control of Methotrexate disodium salt
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Utilizes characteristic absorption peaks of methotrexate at specific wavelengths (e.g., approximately 302 nm and 372 nm) for identification. |
| Infrared Spectroscopy (IR) | Confirms structural consistency by comparing characteristic functional group absorption peaks in the sample's IR spectrum with those of the reference standard. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase chromatographic column with phosphate buffer-methanol or acetonitrile as the mobile phase, and UV detection to quantitatively determine the main component content. |
| Non-aqueous Titration | Titration performed in a non-aqueous solvent using perchloric acid titrant, with endpoint determined by potentiometry or indicator method, followed by content calculation. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separates the main peak from impurity peaks using gradient or isocratic elution; impurity levels are controlled via area normalization or external standard method. |
| Drying Loss | Thermogravimetric Analysis / Drying Loss Method | Drying the sample to constant weight at a specified temperature (e.g., 105°C), then calculating the percentage of mass loss to assess moisture and volatile substance content. |
| Residual Solvents | Gas Chromatography (GC), Headspace Injection | Based on ICH Q3C guidelines, uses a capillary column for separation and FID or MS detector to measure residual organic solvent levels. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determines total or individual levels of lead, arsenic, cadmium, mercury, etc., ensuring compliance with pharmacopoeial limits. |
| pH Value | pH Meter Measurement | Measures the acidity or alkalinity of a prepared aqueous solution using a calibrated pH meter to ensure compliance with formulation stability requirements. |
| Solution Clarity and Color | Visual Color/Opacity Comparison | Visually evaluates clarity and color by comparison with standardized reference solutions or turbidity standards to confirm they fall within acceptable ranges. |
| Bacterial Endotoxins | LAL Assay (Limulus Amebocyte Lysate) | Relies on the coagulation reaction between LAL reagent and endotoxins; detects endotoxin levels using dynamic chromogenic or gel clot methods. |
| Microbial Limits | Pharmacopoeial Microbiological Testing Methods | Tests total aerobic bacteria, mold, and yeast counts, as well as control organisms (e.g., Escherichia coli), using membrane filtration or plate count methods. |
Technical Specifications of Methotrexate disodium salt
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
| Identification (NMR) | Consistent with reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methotrexate disodium salt
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methotrexate disodium salt
Packaging of Methotrexate disodium salt
Industrial Methotrexate disodium salt Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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