L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 74163-81-8 |
| Product name | L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of chiral drug intermediates for antitumor, antiviral, and central nervous system therapeutics | Construction of chiral centers via asymmetric catalytic hydrogenation or enzymatic catalysis to achieve selective (S)-configuration synthesis |
| Organic Synthesis | Chiral ligands or catalyst precursors for asymmetric synthesis reactions | Preparation of functionalized derivatives through derivatization reactions such as esterification and amidation; participation in asymmetric alkylation, aldol condensation, and related reactions |
| Pesticides | Structural building block for novel pesticide active ingredients, enabling development of highly effective, low-toxicity insecticides | Enhancement of biological activity through incorporation of heterocyclic structures; improvement of selectivity and environmental compatibility leveraging its chirality |
| Polymer Materials | Synthesis of functional polymers with defined stereostructures | Participation as a monomer in ring-opening polymerization or condensation polymerization to control polymer stereoregularity and performance |
| Biochemical Research | Biologically active molecular probe for studying receptor binding mechanisms and enzyme inhibition | Application in target identification, structure–activity relationship studies, and drug screening platform development via labeling or structural modification |
Manufacturing Quality Control of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at ~210–230 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separation on a chiral stationary phase (e.g., Chiralpak AD-H, OD-H) with UV detection; ee calculated from peak area ratio of (S)- and (R)-enantiomers. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection, quantifying common solvents (e.g., methanol, ethyl acetate, toluene) against internal/external standards per ICH Q3C. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic elements (Pb, Cd, Hg, As) after acid digestion, achieving sub-pptr detection limits per ICH Q3D. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Residue on Ignition | Gravimetric Analysis | Mass determination of inorganic residue after controlled high-temperature ashing (700–800 °C) per USP <281>. |
| Optical Rotation | [α]D Measurement | Specific rotation measured in solution (e.g., 1% w/v in HCl or MeOH) using a digital polarimeter at 589 nm and 20–25 °C. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Detection and quantification of structurally related impurities (e.g., decarboxylated, oxidized, or dimeric species) under stressed conditions (acid/base/oxidative/thermal). |
| pH (Aqueous Suspension) | Potentiometric pH Measurement | pH of a defined suspension (e.g., 1% w/v in water) measured using calibrated pH electrode per USP <791>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie theory to determine D10, D50, D90 values per ISO 13320. |
| Microbial Contamination | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, Salmonella) per USP <61> and <62>. |
Technical Specifications of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Optical Rotation | -169.0 to -163.0° (c=1, in 1M HCl) |
| Melting Point | 218.0 to 222.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Safety Information of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Industrial L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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