p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 74288-40-7 |
| Product name | p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 74288-40-7
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 74288-40-7 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 74288-40-7
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of carbapenem antibiotics (e.g., imipenem) | Acylative coupling of the imipenem core with side-chain moieties (e.g., thiazolidine carboxylic acid) via chemical synthesis or enzymatic catalysis to form the complete, biologically active molecule |
Manufacturing Quality Control of 74288-40-7
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Analyzes the main component content using a reverse-phase chromatographic column, phosphate buffer solution-organic phase as the mobile phase, and a UV detector (e.g., 220 nm) for quantification, in accordance with pharmacopoeia requirements. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separes parent nucleus and related degradation products or synthetic byproducts using a gradient elution program. The content of each impurity is calculated using peak area normalization or external standard method to control the limits. |
| Residual Solvents | Gas Chromatography (GC, Headspace Injection) | In accordance with ICH Q3C guidelines, organic residual solvents (e.g., ethyl acetate, methanol) are measured using a capillary column and FID detector with headspace injection to ensure compliance with safety limits. |
| Water Content Determination | Karl Fischer Titration Method | Determines water content in the sample using volumetric or coulometric methods to control the impact on stability and purity. Typically requires ≤0.5%. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | After sample digestion, measures residues of lead, cadmium, mercury, arsenic, and other elements to comply with ICH Q3D elemental impurity limit requirements. |
| Optical Rotation | Polarimeter Method | Measures optical rotation at a specified wavelength (e.g., sodium D line) after preparing a solution of certain concentration, used for identification and controlling chiral purity. |
| pH Value | pH Meter Method | Measures pH directly using a calibrated pH meter after preparing an aqueous solution of specified concentration, reflecting its acid-base characteristics that affect formulation stability. |
| Appearance and Properties | Visual Inspection and Physical Testing | Observes physical properties such as color, crystal form, and odor. Should be white to off-white crystalline powder without any unusual odor, complying with standard descriptions. |
| Loss on Drying | Oven-Drying Method (105°C Constant Weight) | Dries the sample at a specified temperature until constant weight is achieved, calculating the percentage of weight loss to assess volatile substances and adsorbed water content. |
| Bacterial Endotoxins | Limulus Amebocyte Lysate (LAL) Method | Uses lysate from horseshoe crab blood cells reacting with endotoxins to form gel or show color change for quantitative detection of endotoxin levels. Strictly controlled for injectable raw materials (e.g., <0.25 EU/mg). |
Technical Specifications of 74288-40-7
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.3% |
| Water Content (KF) | <=0.5% |
| Melting Point | 162°C - 166°C |
| Optical Rotation | -25.0° to -29.0° (c=1, in water) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 74288-40-7
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 74288-40-7
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Industrial 74288-40-7 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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