N-Boc-exo-3-aminotropane Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 744183-20-8 |
| Product name | N-Boc-exo-3-aminotropane |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for N-Boc-exo-3-aminotropane
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Boc-exo-3-aminotropane Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Boc-exo-3-aminotropane
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediates for synthesizing dopamine D3 receptor-selective agonists (e.g., PF-514273) and neuroprotective drug candidates | Used in chiral resolution or asymmetric synthesis, followed by Boc deprotection and derivatization reactions (e.g., acylation or sulfonylation) to construct the core structure of the target molecule |
| Pharmaceutical R&D | Critical precursor for tropane scaffold modification, enabling design of G protein-coupled receptor (GPCR) modulators targeting the central nervous system | Applied as a rigid three-dimensional scaffold to introduce stereochemically defined substituents during structure–activity relationship (SAR) studies, thereby optimizing receptor binding affinity and metabolic stability |
| Fine Chemicals | High-value chiral building blocks supporting custom synthesis services offered by CROs and CDMOs | Processed via Boc-protecting-group-compatible transformations—including palladium-catalyzed cross-coupling, reductive amination, and Mitsunobu reactions—to achieve structural diversification |
Manufacturing Quality Control of N-Boc-exo-3-aminotropane
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and identification/quantification of structurally related impurities (e.g., de-Boc, N-Boc-endo isomer, residual solvents, synthesis intermediates) using gradient elution and spectral confirmation. |
| Residual Solvents | GC-FID or GC-MS | Headspace GC analysis with flame ionization detection or mass spectrometry to quantify ICH Q3C-classified solvents (e.g., dichloromethane, methanol, THF, toluene). |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS or ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni, Pd) after acid digestion, based on atomic emission or mass spectrometric detection. |
| Optical Rotation | [α]D Measurement (Polarimetry) | Determination of specific optical rotation at 589 nm using a sodium lamp to confirm chiral integrity and enantiomeric identity. |
| Residual Palladium | ICP-MS | Ultra-trace quantification of Pd catalyst residue post-hydrogenation steps via high-sensitivity mass spectrometry after microwave-assisted digestion. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed powder to determine D10, D50, D90 values based on light scattering intensity vs. particle size. |
| Loss on Drying (LOD) | Thermogravimetric Analysis (TGA) or Oven Drying | Measurement of mass loss upon controlled heating (e.g., 105 °C, 2 h) to assess volatile content including residual solvents and moisture. |
| pH of Aqueous Suspension | pH Meter (10% w/v in Water) | Direct potentiometric measurement of hydrogen ion activity in a standardized suspension to assess acidic/basic degradation products or salt formation. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms (total viable count), yeasts, molds, and absence testing for specified pathogens per USP <61>/<62>. |
Technical Specifications of N-Boc-exo-3-aminotropane
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | +15.0 to +19.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of N-Boc-exo-3-aminotropane
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Boc-exo-3-aminotropane
Packaging of N-Boc-exo-3-aminotropane
Industrial N-Boc-exo-3-aminotropane Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply