2-(Trimethylsilyl)ethoxymethyl chloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 76513-69-4 |
| Product name | 2-(Trimethylsilyl)ethoxymethyl chloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-(Trimethylsilyl)ethoxymethyl chloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-(Trimethylsilyl)ethoxymethyl chloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-(Trimethylsilyl)ethoxymethyl chloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Protecting group for aliphatic and phenolic hydroxyl groups | Used as a reagent to introduce the SEM protecting group during the synthesis of drug molecules and intermediates, protecting sensitive hydroxyl functionalities from subsequent reaction steps (e.g., oxidation, reduction, nucleophilic substitution), thereby improving route selectivity and yield. |
| Pharmaceutical Chemicals | Protecting group for amino groups | Applied to protect amino groups in nitrogen-containing heterocycles (e.g., imidazole, pyrazole) or amine-based drug molecules, preventing side reactions under acidic or other specific reaction conditions. |
| Biochemistry | Base protection in nucleotide synthesis | Used to protect exocyclic amino or hydroxyl groups on nucleobases (e.g., guanine) during the synthesis of nucleosides, nucleotides, and oligonucleotides, preventing deamination or degradation during phosphorylation or coupling reactions. |
| Agrochemicals | Structural modification of agrochemical molecules | Employed in the research and synthesis of novel active agrochemical ingredients to protect specific functional groups and construct complex molecular frameworks. |
| Materials Chemistry | Synthesis of functional organosilicon materials | Leverages its silane functionality in grafting or capping reactions to synthesize organosilicon precursors with tailored surface properties or solubility characteristics. |
| Organic Synthesis | Laboratory reagent for organic synthesis | Serves as a general-purpose protecting reagent widely used in total synthesis of complex natural products and process development for fine chemicals, particularly in reaction systems requiring acid-stable protecting groups. |
Manufacturing Quality Control of 2-(Trimethylsilyl)ethoxymethyl chloride
| Test Item | Common Test Method | Method Summary |
|---|---|---|
| Purity (Main Component Content) | Gas Chromatography (GC) | Using a capillary column (e.g., DB-5 or HP-INNOWAX) and FID detector, the main component is quantified by internal or external standard method, separating and measuring TEMCl and common impurities (e.g., unreacted raw materials, hydrolysis products). |
| Water Content | Karl Fischer Titration | Water is quantitatively reacted with an iodine-sulfur dioxide-pyridine-methanol reagent system, and trace moisture in the sample is measured by potentiometric or coulometric methods, suitable for controlling its moisture-sensitive properties. |
| Chlorine Content (Free or Total Chlorine) | Ion Chromatography (IC) or Argentometric Titration | Ion Chromatography: After sample hydrolysis, Cl⁻ is separated using an anion exchange column and detected by conductivity. Argentometric Titration: In acidic conditions, Cl⁻ from hydrolysis is titrated with AgNO₃ using potassium chromate as indicator. |
| Organic Impurities (By-products) | Gas Chromatography-Mass Spectrometry (GC-MS) | Based on GC separation, unknown structural impurities (e.g., trimethylsilanol, chloroethane derivatives) are identified by mass spectrometry, used for impurity profiling and process optimization. |
| Appearance and Color | Visual Inspection / Color Measurement (APHA) | Observe whether the sample is a colorless to slightly yellow transparent liquid. APHA colorimeter is used for color quantification to assess if colored impurities are generated due to oxidation or decomposition. |
| Density | Density Meter / Pycnometer Method | Density is measured at constant temperature (20°C or 25°C) using a digital density meter or pycnometer, and compared with the standard value (about 1.05–1.08 g/cm³), assisting in purity assessment. |
| Boiling Point / Vapor Pressure | Boiling Point Apparatus / GC Retention Time | Measure the normal boiling point (about 110–120°C) using a boiling point apparatus, or compare GC retention time with reference standards to assess consistency of volatile components. |
| Residual Solvents (e.g., THF, DCM) | GC-MS or Headspace GC | Quantitative analysis of potentially residual organic solvents from production. Headspace injection is used to reduce sample decomposition, and residual levels are calculated using a standard curve method, meeting ICH Q3C requirements. |
| Stability (Degradation Products) | Accelerated Stability Test + GC/HPLC | Place the sample under high temperature (40°C) or high humidity (75% RH), periodically take samples and use GC or HPLC to monitor degradation products (e.g., 2-(trimethylsilyl)ethanol), evaluating storage stability. |
| pH Value (Aqueous System) | pH Meter Method | Dissolve a small amount of the sample in water (rapid hydrolysis), immediately measure the pH of the hydrolyzed solution using a calibrated pH meter (should be acidic, pH≈2–4), assessing hydrolysis extent and neutralizing impurities. |
| Metal Ion Impurities (Fe, Cu, etc.) | ICP-MS or ICP-OES | After acid digestion, trace metal ions in the sample are detected by inductively coupled plasma mass spectrometry or optical emission spectrometry, ensuring compliance with metal impurity limits for pharmaceutical or electronic-grade materials (e.g., <1 ppm). |
Technical Specifications of 2-(Trimethylsilyl)ethoxymethyl chloride
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (by GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.425–1.435 |
| Relative Density (20°C/25°C) | 0.92–0.94 g/cm³ |
| Odor | Characteristic chlorinated organosilicon odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-(Trimethylsilyl)ethoxymethyl chloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-(Trimethylsilyl)ethoxymethyl chloride
Safety Information of 2-(Trimethylsilyl)ethoxymethyl chloride
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 2-(Trimethylsilyl)ethoxymethyl chloride
Industrial 2-(Trimethylsilyl)ethoxymethyl chloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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