Divalproex sodium Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 76584-70-8 |
| Product name | Divalproex sodium |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Divalproex sodium
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Divalproex sodium Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Divalproex sodium
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for antiepileptic drugs | Used as the sodium salt of valproic acid in the synthesis of antiepileptic formulations, acting by suppressing neuronal hyperexcitability |
| Pharmaceuticals | Bipolar disorder treatment | Applied for mood stabilization and modulation of central nervous system function, commonly used in the preparation of oral tablets or extended-release dosage forms |
| Pharmaceuticals | Migraine prophylaxis | Applied to reduce migraine attack frequency by modulating cerebral gamma-aminobutyric acid (GABA) levels, intended for long-term preventive therapy |
Manufacturing Quality Control of Divalproex sodium
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with the reference standard spectrum to confirm functional groups and structural characteristics. |
| Sodium Ion Reaction (Flame Photometry or Atomic Absorption) | Utilize the characteristic yellow flame produced by sodium ions in a flame or measure sodium content via atomic absorption spectroscopy for auxiliary identification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase HPLC with a C18 column as the stationary phase and UV detector (typically 210–220 nm) to determine the main component content. |
| Acid-Base Titration | Determine content indirectly by titrating propionic acid released after hydrolysis of sodium valproate using a standardized alkaline solution (rarely used for finished products). | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employ gradient or isocratic elution HPLC to separate and quantify potential impurities (e.g., valproic acid, allylvalproic acid). |
| pH Value | pH Meter Method | Directly measure the pH of a defined concentration of test solution using a pH meter to ensure acidity/alkalinity meets pharmacopoeial requirements (typically 4.5–7.5). |
| Drying Loss | Thermogravimetric Analysis (TGA) or Constant Pressure Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight, then calculate the percentage loss due to moisture and volatile substances. |
| Residue on Ignition | High-Temperature Incineration Method | Ignite the sample at high temperature (approximately 600–800°C), then weigh the residual inorganic matter to assess inorganic impurity levels. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect residual heavy metals such as lead, cadmium, mercury, and arsenic using atomic absorption or inductively coupled plasma mass spectrometry. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection GC to detect organic solvents potentially remaining from synthesis or purification processes (e.g., methanol, acetone). |
| Microbial Limits | Film Filtration Method / Plate Count Method | Test for total aerobic bacteria, mold/yeast count, and control organisms (e.g., Escherichia coli) according to requirements in Chinese Pharmacopoeia or USP. |
| Solution Clarity and Color | Visual Turbidity/Color Comparison Method | Compare the clarity and color of the test solution visually with standard turbidity or color standards to verify compliance with specifications. |
Technical Specifications of Divalproex sodium
| Test Item | Specification |
|---|---|
| Appearance | Colorless to light yellow clear liquid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
| Optical Rotation | -12.0° to -14.0° (c=1, H2O) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Divalproex sodium
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Divalproex sodium
Packaging of Divalproex sodium
Industrial Divalproex sodium Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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