Boc-3-(2-Naphthyl)-D-alanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 76985-10-9 |
| Product name | Boc-3-(2-Naphthyl)-D-alanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Boc-3-(2-Naphthyl)-D-alanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Boc-3-(2-Naphthyl)-D-alanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Boc-3-(2-Naphthyl)-D-alanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a protecting group in drug synthesis to prepare compounds with specific biological activity | Reacted with target molecules to form Boc-protected intermediates, followed by deprotection under appropriate conditions to yield the desired product |
| Chemical Synthesis | Employed as a chiral auxiliary to control product stereochemistry in asymmetric synthesis | Leveraged for its chiral properties during organic synthesis to direct reaction pathways, thereby enhancing product selectivity and purity |
| Research & Development | Applied in the development of novel pharmaceuticals or materials | Incorporated into diverse chemical structures to evaluate its impact on final product performance and to explore new application areas |
Manufacturing Quality Control of Boc-3-(2-Naphthyl)-D-alanine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Physical Form | Visual Inspection + Melting Point Determination | Observe the sample as white to off-white crystalline powder; determine melting point range (literature value approximately 115–120 °C); compare with standard values to assess moisture uptake, discoloration, or impurity contamination. |
| Identification (Structural Confirmation) | Infrared Spectroscopy (IR) | Confirm presence of functional groups by comparing characteristic IR absorption peaks (e.g., C=O stretching of Boc group ~1700 cm⁻¹, N-H bending ~1540 cm⁻¹, aromatic C=C of naphthalene ring ~1600, 1580 cm⁻¹) with reference spectrum. |
| Nuclear Magnetic Resonance Spectroscopy (¹H NMR / ¹³C NMR) | Dissolve in DMSO-d₆ or CDCl₃ and analyze characteristic proton chemical shifts (e.g., t-Bu methyl protons of Boc ~1.4 ppm, aromatic protons of naphthalene ring ~7.2–8.0 ppm, α-CH ~4.2–4.5 ppm) to confirm molecular structure. | |
| Assay (Purity) | High-Performance Liquid Chromatography (HPLC) | Use a C18 reversed-phase column with water-acetonitrile gradient elution; detect at UV wavelength 220–254 nm (absorption of naphthalene ring); calculate percentage of main peak area to quantify active ingredient content (typically required ≥98%). |
| Related Substances (Impurity Profile) | HPLC (Impurity Detection Method) | Under the same HPLC conditions, lower detection wavelength to 210 nm or extend gradient to separate and quantify known/unknown impurities (e.g., de-Boc product, D/L isomers, oxidation products). Limits are typically ≤1.0% for any individual impurity and ≤2.0% for total impurities. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with DB-624 or HP-INNOWAX column to detect residual solvents such as ethanol, ethyl acetate, dichloromethane, THF, etc., ensuring compliance with ICH Q3C permissible limits. |
| Water Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric method; control water content ≤0.5% to prevent hydrolysis or stability issues during storage. |
| Specific Optical Rotation (Optical Purity) | Polarimetry | Prepare sample solution (e.g., 1% in ethanol), measure specific rotation [α]₂₀ᴅ at 20°C; expected value is +10° to +20° (depending on solvent and concentration), confirming D-configuration and absence of L-isomer contamination. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of heavy metals (e.g., Pb, Cd, As, Hg, Cu) according to pharmacopoeial methods (e.g., USP <231> or EP 2.5.12), controlling concentrations at ppm level (e.g., ≤10 ppm). |
| Inorganic Impurities (e.g., Chlorides, Sulfates) | Ion Chromatography (IC) or Colorimetric Methods | Detect anions such as Cl⁻, SO₄²⁻ using ion chromatography, or apply classical colorimetric methods (e.g., silver nitrate precipitation for chlorides), ensuring compliance with pharmaceutical standards. |
| Solubility | Shake Flask Method / Quantitative Dissolution Test | Determine equilibrium solubility in solvents such as water, ethanol, DMF, ethyl acetate; used as reference for formulation development. Typically slightly soluble in water, readily soluble in organic solvents. |
| Particle Size Distribution (if applicable) | Laser Diffraction | If intended as an active pharmaceutical ingredient (API) powder for formulation, measure D10, D50, D90 to control particle size distribution for uniform mixing and compressibility. |
Technical Specifications of Boc-3-(2-Naphthyl)-D-alanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Optical Rotation | -43.0° ± 2.0° (c=1, in 1M HCl) |
| Melting Point | 178°C - 182°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Boc-3-(2-Naphthyl)-D-alanine
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NMR Spectra of Boc-3-(2-Naphthyl)-D-alanine
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Industrial Boc-3-(2-Naphthyl)-D-alanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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