Tris(hydroxymethyl)aminomethane Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 77-86-1 |
| Product name | Tris(hydroxymethyl)aminomethane |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Tris(hydroxymethyl)aminomethane
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Tris(hydroxymethyl)aminomethane Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Tris(hydroxymethyl)aminomethane
| Industry | Application | Process |
|---|---|---|
| Biomedical Research | Buffer component for electrophoresis, DNA/RNA extraction, PCR, and related assays | Formulated into Tris-HCl buffer solutions (pH 7.0–9.0) to maintain stable pH in reaction systems |
| Pharmaceutical Industry | pH adjuster and stabilizer in drug formulations, including injectables, ophthalmic solutions, and protein-based therapeutics | Added to final sterile formulations to control pH within physiologically compatible ranges (e.g., 7.2–7.6) |
| Cosmetics | pH adjuster and skin-conditioning agent in conditioners, shampoos, and skincare products | Neutralized with acid (e.g., hydrochloric acid) prior to incorporation to ensure product pH of 4.5–6.5, supporting skin barrier function |
| Molecular Diagnostics Reagents | Core buffering component in nucleic acid detection kits | Serves as a foundational component in RT-PCR and isothermal amplification (e.g., LAMP) reaction buffers to ensure enzymatic activity and specificity |
| Cell Culture | Supplement for pH adjustment of basal media (e.g., MEM, DMEM) | Used in conjunction with CO₂ equilibrium systems to enhance pH buffering capacity, particularly under low-CO₂ or CO₂-free culture conditions |
Manufacturing Quality Control of Tris(hydroxymethyl)aminomethane
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state. Qualified products should be white crystals or crystalline powder with no visible impurities. |
| pH Value | pH Meter Method | Dissolve the sample in water at a specified concentration (e.g., 0.1 mol/L), then measure pH using a calibrated pH meter (typically 7.0–9.0). |
| Content Determination | Acid-Base Titration Method | Titrate with standardized hydrochloric acid solution, using methyl red or bromocresol green as indicator; calculate the active ingredient content (≥99.0%). |
| Drying Loss | Drying Method (Loss on Drying) | Dry the sample at 105°C to constant weight and calculate the percentage of mass loss (typically ≤0.5%). |
| Residue on Ignition | High-Temperature Incineration Method | Incinerate the sample at high temperature (e.g., 800°C), weigh the residual ash to assess inorganic impurity levels (typically ≤0.1%). |
| Heavy Metals | Heavy Metal Test Method (Thioacetamide Method) from Chinese Pharmacopoeia | React under specified conditions with thioacetamide to produce coloration, compare with standard lead solution; limit typically ≤20 ppm. |
| Chlorides | Silver Nitrate Turbidimetric Method | React with silver nitrate in nitric acid medium to form turbidity due to silver chloride precipitate; compare with standard sodium chloride solution (limit ≤0.01%). |
| Sulfates | BaCl₂ Turbidimetric Method | React with barium chloride in hydrochloric acid medium to form barium sulfate precipitate; compare with standard potassium sulfate solution (limit ≤0.02%). |
| Ammonium Salts | Nessler's Reagent Colorimetric Method | React with Nessler's reagent to form yellow-brown complex; compare with standard ammonium solution (limit ≤0.02%). |
| Insoluble Matter in Water | Filtration-Drying-Weighing Method | Dissolve sample in water, filter, dry and weigh the residue to assess insoluble impurities (typically ≤0.01%). |
| UV Absorption Impurities | UV-Visible Spectrophotometry | Measure absorbance at specified wavelengths (e.g., 230 nm, 260 nm, 280 nm) to evaluate organic impurity levels. |
| Moisture Content | Karl Fischer Titration Method | Determine moisture content accurately using either volumetric or coulometric Karl Fischer titration. |
| Related Substances / Impurities | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase chromatographic column and appropriate mobile phase for separation; quantify impurity peaks outside the main peak by area normalization or external standard method. |
Technical Specifications of Tris(hydroxymethyl)aminomethane
| Test Item | Specification |
|---|---|
| Appearance | White crystal powder |
| Content, % | 99.5%-101.0% |
| Melting Point | 168-172.0°C |
| Water Insoluble | <0.03% |
| Strong heat residue | <0.05% |
| Loss on drying | <0.2% |
| pH | 10.0-11.5 |
| Fe | ≤10ppm |
| SO4 | ≤10ppm |
| Cl | ≤10ppm |
| Heavy Metal(Pb) | ≤10ppm |
| 40% water solution 260nm | ≤0.1 |
| 40% water solution 280nm | <0.07 |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Tris(hydroxymethyl)aminomethane
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Tris(hydroxymethyl)aminomethane
Safety Information of Tris(hydroxymethyl)aminomethane
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Tris(hydroxymethyl)aminomethane
Industrial Tris(hydroxymethyl)aminomethane Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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