1-Boc-3-iodopyrrolidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 774234-25-2 |
| Product name | 1-Boc-3-iodopyrrolidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-3-iodopyrrolidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-3-iodopyrrolidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-3-iodopyrrolidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing pyrrolidine-containing active pharmaceutical ingredients (APIs), such as NK1 receptor antagonists and DPP-4 inhibitor candidates | Under inert atmosphere, aryl/heteroaryl substituents are introduced via palladium-catalyzed cross-coupling (e.g., Stille, Suzuki, or Heck reactions); followed by BOC deprotection and salt formation or further functionalization |
| Organic Synthesis | Chiral azaheterocyclic building block for constructing complex molecules bearing chiral nitrogen centers | Used in asymmetric alkylation, acylation, or cycloaddition reactions with chiral auxiliaries or catalysts; also serves as a nucleophile in SN2 substitution reactions (iodine acts as a good leaving group) |
| Agrochemical R&D | Applied in designing novel insecticidal or plant growth-regulating lead compounds featuring nitrogen-containing heterocyclic structures | Metal-catalyzed C–N or C–C bond formation reactions involving the iodine atom to construct bioactive fused three- or four-membered heterocyclic systems |
Manufacturing Quality Control of 1-Boc-3-iodopyrrolidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-230 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally similar impurities using gradient HPLC-UV; identification supported by retention time matching and system suitability. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., acetone, methanol, ethyl acetate) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration where iodine reacts stoichiometrically with water in a pyridine-methanol solvent system. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, Ni) using inductively coupled plasma mass spectrometry with isotope-dilution calibration. |
| Residual Iodine | Ion Chromatography | Separates and quantifies iodide ion using anion-exchange column with suppressed conductivity detection after aqueous extraction. |
| Acid Value | Acid-Base Titration | Measures free acidic impurities by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| Chloride Content | Potentiometric Titration | Quantifies chloride ions using silver nitrate titrant with silver-sulfide indicator electrode and automatic endpoint detection. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measures chiral purity by determining rotation angle of plane-polarized light in solution at specified concentration and wavelength (589 nm). |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder size distribution using Mie scattering theory applied to laser diffraction patterns from dispersed sample. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by high-temperature incineration (600-800 C) followed by precise weighing of residual residue. |
Technical Specifications of 1-Boc-3-iodopyrrolidine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.5% (by GC) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference standard |
| Optical Rotation | -15.0° to -25.0° (c=1, in CHCl3) |
| Solubility | Freely soluble in dichloromethane, chloroform, and ethyl acetate; slightly soluble in water |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-3-iodopyrrolidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-3-iodopyrrolidine
Packaging of 1-Boc-3-iodopyrrolidine
Industrial 1-Boc-3-iodopyrrolidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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