cis-4-Hydroxy-D-proline hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 77449-94-6 |
| Product name | cis-4-Hydroxy-D-proline hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for cis-4-Hydroxy-D-proline hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk cis-4-Hydroxy-D-proline hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of cis-4-Hydroxy-D-proline hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral building block for synthesizing peptide-based drugs and protease inhibitors | Participates in condensation reactions as a proline derivative via solid-phase or liquid-phase peptide synthesis |
| Pharmaceuticals | Intermediate for antiviral drugs and neuroprotective agents | Serves as a chiral precursor to introduce stereocenters in asymmetric catalytic hydrogenation or enzymatic transformations |
| Cosmetics | Active ingredient for skin moisturization and anti-aging formulations | High-purity product obtained via chemical synthesis or microbial fermentation, formulated into topical preparations |
| Biochemistry | Used to study collagen stabilization mechanisms and protein folding models | Applied as a reference standard or probe molecule in in vitro collagen triple-helix structure modeling |
| Pesticides | Chiral auxiliary for synthesizing selective fungicides or plant growth regulators | Functions as a chiral ligand or template to control stereoselectivity in asymmetric synthesis |
Manufacturing Quality Control of cis-4-Hydroxy-D-proline hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with UV detection | Quantitative determination using reverse-phase HPLC and UV absorbance at 200-220 nm, comparing peak area to a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation of enantiomers on a chiral stationary phase followed by UV detection and calculation of ee from peak area ratio. |
| Loss on Drying (LOD) | Gravimetric thermogravimetry | Mass loss measured after drying a sample at 105 C for 3 hours under atmospheric pressure. |
| Residual Solvents | Gas Chromatography (GC) with FID | Identification and quantification of volatile organic solvents using headspace GC and flame ionization detection. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification of trace metals after acid digestion, based on elemental mass-to-charge ratio detection. |
| Chloride Content | Potentiometric titration with AgNO3 | Titration with silver nitrate solution using a silver indicator electrode; endpoint detected by potential change. |
| pH (1% aqueous solution) | pH meter measurement | Electrochemical measurement of hydrogen ion activity in a 10 mg/mL aqueous solution at 25 C. |
| Specific Optical Rotation | [alpha]D | Measurement of plane-polarized light rotation using a digital polarimeter at 20 C and sodium D-line (589 nm). |
| Related Substances | HPLC with UV detection | Detection and quantification of structurally related impurities using gradient reverse-phase HPLC and UV monitoring. |
| Microbial Limits | Membrane filtration and plate count | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, Salmonella) per pharmacopeial methods. |
Technical Specifications of cis-4-Hydroxy-D-proline hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 215~219°C |
| Optical Rotation | +10.0 to +12.0° (c=1, H2O) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of cis-4-Hydroxy-D-proline hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of cis-4-Hydroxy-D-proline hydrochloride
Safety Information of cis-4-Hydroxy-D-proline hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of cis-4-Hydroxy-D-proline hydrochloride
Industrial cis-4-Hydroxy-D-proline hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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