Benzyl (S)-(-)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate p-toluenesulfonic acid salt Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 77497-97-3 |
| Product name | Benzyl (S)-(-)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate p-toluenesulfonic acid salt |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 77497-97-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 77497-97-3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 77497-97-3
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate for the development of antipsychotic and central nervous system (CNS) drugs | Prepared via chiral synthesis to obtain (S)-(−)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid benzyl ester, followed by salt formation with p-toluenesulfonic acid, for constructing bioactive molecules with defined stereochemistry |
| Organic Synthesis | Precursor to chiral catalysts or chiral auxiliaries | Used as a chiral template in asymmetric synthesis to construct complex molecular architectures and enhance stereoselectivity |
| Fine Chemicals | Intermediate for synthesizing high-value fine chemicals | Employed in multi-step reaction sequences—including esterification, reduction, and coupling—to produce functionalized isoquinoline derivatives |
Manufacturing Quality Control of 77497-97-3
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~220 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Purity | Chiral HPLC | Separation on a chiral stationary phase (e.g., Chiralpak AD-H) with UV detection to resolve (S)- and (R)-enantiomers and calculate enantiomeric excess (ee). |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., methanol, ethyl acetate, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, with detection at sub-pptr levels. |
| Inorganic Impurities (Sulfate, Chloride) | Ion Chromatography (IC) | Separation and conductivity detection of anions (SO₄²⁻, Cl⁻) in aqueous extract; conforms to USP <231> and EP 2.4.19. |
| Related Substances | HPLC-UV (Forced Degradation) | Stability-indicating method using gradient HPLC-UV to detect and quantify process-related and degradation impurities under oxidative, acidic, basic, thermal, and photolytic stress. |
| Residual Palladium | ICP-OES | Quantification of Pd catalyst residue after microwave-assisted nitric/hydrochloric acid digestion, using plasma emission spectroscopy. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs, indicating crystallinity and purity. |
| Specific Optical Rotation | [α]D | Measurement of plane-polarized light rotation in solution at 589 nm (Na D-line) to confirm chiral identity and batch-to-batch consistency. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersion via light scattering to determine D10, D50, D90 values relevant for filtration and formulation handling. |
| Microbial Contamination | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and absence of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 77497-97-3
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Optical Rotation | -62.0 to -59.0 deg (c=1, in CHCl3) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 77497-97-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 77497-97-3
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Industrial 77497-97-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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