5-Fluoro-2-nitropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 779345-37-8 |
| Product name | 5-Fluoro-2-nitropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Fluoro-2-nitropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Fluoro-2-nitropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Fluoro-2-nitropyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key pharmaceutical intermediate | Used in the synthesis of protein kinase inhibitors (e.g., CDK and PI3K inhibitors) and the molecular scaffolds of anticancer agents. |
| Pharmaceutical Chemicals | Construction of fluorinated pyridine structural units | Applied in nucleophilic aromatic substitution (SNAr) reactions between fluorine and nucleophiles to replace fluorine with amino or alkoxy groups, thereby constructing functionalized pyridine derivatives. |
| Pharmaceutical Chemicals | Drug molecule building block | Reduced (e.g., via iron powder reduction or catalytic hydrogenation) from nitro to amino group to yield 2-amino-5-fluoropyridine, which serves as a precursor for subsequent amidation or coupling reactions. |
| Organic Synthesis | Specialized organic synthesis reagent | Employed as an electrophile or substrate in coupling reactions—including Suzuki and Buchwald-Hartwig couplings—to construct complex bipyridyl or arylamine compounds. |
| Research Reagents | Laboratory R&D | Used in new drug screening, synthetic methodology development, and custom synthesis of bioactive molecules. |
Manufacturing Quality Control of 5-Fluoro-2-nitropyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and peak area normalization. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection for quantification of common solvents (e.g., methanol, acetone, DMF) against external calibration curves. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via electrochemical endpoint detection. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, using isotopic dilution or external calibration. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anion using suppressed conductivity detection after aqueous extraction. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 700-800 C followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, using calibrated digital apparatus per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion via laser scattering to obtain D10, D50, D90 values per ISO 13320. |
| Bulk Density | ASTM D1895 | Measurement of mass per unit volume for freely settled powder in a standardized cylinder. |
| Loss on Drying | Thermogravimetric Analysis | Weight loss measured after heating at 105 C for 2 hours under controlled airflow, per USP <731>. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light source, indicating chiral purity or absence of optically active contaminants. |
Technical Specifications of 5-Fluoro-2-nitropyridine
| Test Item | Specification |
|---|---|
| Appearance | Light Yellow to Yellow Solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 58–62°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Fluoro-2-nitropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Fluoro-2-nitropyridine
Packaging of 5-Fluoro-2-nitropyridine
Industrial 5-Fluoro-2-nitropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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