China Factory Direct
|
|
| CAS number | 7803-58-9 |
| Product name | Sulfamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeIndustrial GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing sulfonylurea herbicides | Prepared via condensation reaction of sulfonyl chlorides with amines |
| Pharmaceuticals | Used to synthesize sulfonamide antimicrobial agents (e.g., sulfadiazine, sulfamethoxazole) | Prepared via nucleophilic substitution of benzenesulfonyl chloride with aromatic or heterocyclic amines |
| Dyes | Intermediate for azo dyes | Coupled with diazonium salts to form colored sulfonamide derivatives |
| Polymers | Used as a crosslinking agent or modifier for polymers | Reacts with epoxy resins or polyurethane prepolymers to introduce sulfonamide functional groups |
| Analytical Chemistry | Acts as a chelating agent or colorimetric reagent for metal ions | Forms stable complexes with heavy metal ions in solution for detection |
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase column (e.g., C18) and a UV detector (commonly set at 254 nm or adjusted based on the specific sulfonamide) to quantitatively analyze sulfonamide content by comparison with reference standards. Offers high sensitivity and resolution, suitable for quality control of both active pharmaceutical ingredients and finished formulations. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employs gradient or isocratic elution to separate the main component from potential impurities such as synthesis intermediates and degradation products. Impurity levels are calculated using peak area normalization or external standard methods to assess purity. |
| Residual Solvents | Gas Chromatography (GC) | In accordance with ICH guidelines, detects residual organic solvents (e.g., methanol, ethanol, acetone, dichloromethane) used during manufacturing. Typically uses headspace sampling coupled with gas chromatography and FID detection to ensure compliance with safety limits. |
| Water Content | Karl Fischer Titration | Accurately determines moisture content in sulfonamide raw materials. Available in volumetric and coulometric methods, suitable for trace water detection, preventing moisture-related impacts on stability and storage. |
| Polymorphic Form Analysis | X-Ray Powder Diffraction (XRD) | Used to identify different crystalline forms of sulfonamides, ensuring consistent polymorphic form, which affects solubility, stability, and bioavailability. A key technique for solid dosage form quality control. |
| Melting Point | Melting Point Determination | Determines the melting temperature range of sulfonamides using a melting point apparatus. Melting point is an important physical parameter for assessing compound identity and purity, with pure substances typically exhibiting a sharp and defined melting range. |
| Identification | Infrared Spectroscopy (IR) | Confirms the structure of sulfonamides by comparing sample spectra with reference spectra, identifying characteristic absorption peaks (e.g., S=O stretching vibrations around 1350 cm⁻¹ and 1150 cm⁻¹, N–H bending). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detects residual toxic elements such as lead, cadmium, mercury, and arsenic. Samples are digested prior to analysis to ensure compliance with pharmacopoeial limits for heavy metals. |
| Particle Size Distribution | Laser Particle Size Analysis | Measures the particle size distribution of sulfonamide powders, which influences dissolution rate, flowability, and performance in formulation processes—particularly critical in solid dosage forms. |
| Microbial Limits | Microbial Limits Testing | Performs tests for total aerobic microbial count, total combined molds and yeasts count, and specified control organisms (e.g., Escherichia coli) according to requirements of the Chinese Pharmacopoeia or USP, ensuring microbial safety of non-sterile pharmaceuticals. |
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 164°C - 168°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
|
|
|
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.