2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 78441-62-0 |
| Product name | 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Intermediate for famotidine | Serves as a key side-chain structural unit in the synthesis of famotidine active pharmaceutical ingredient (API), via condensation or cyclization reactions |
Manufacturing Quality Control of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with water-acetonitrile or methanol as mobile phase (often containing 0.1% formic acid or trifluoroacetic acid to adjust pH), and UV detection (210–254 nm). The main component content is calculated using external standard method or area normalization, effectively separating impurities and degradation products. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Extends run time or uses gradient elution under the above HPLC conditions to detect potential impurities such as residual starting materials, synthetic by-products (e.g., unreacted halides, oxidized sulfide products, dimers, etc.). Coupling with mass spectrometry (MS) allows preliminary structural identification of unknown impurities. |
| Water Content | Karl Fischer Titration | Suitable for trace moisture determination. Due to the presence of amine groups that may react with reagents, methanol-pyridine type reagents are recommended, with correction for interference to ensure accurate results. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection is used with DB-624 or HP-INNOWAX columns and FID detector to analyze residual solvents from synthesis (e.g., ethanol, acetone, DMF, dichloromethane), in compliance with ICH Q3C guidelines. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After microwave digestion of the sample, levels of heavy metals such as lead, cadmium, mercury, arsenic, and copper are determined, meeting pharmacopeial limits (e.g., USP/EP <10–20 ppm). |
| Ammonium Ions / Free Amine Content | Ion Chromatography (IC) or Acid-Base Titration | Ion chromatography detects free ethylenediamine or dimethylamine impurities; alternatively, non-aqueous titration (with perchloric acid) measures total alkalinity to indirectly assess primary/secondary amine content. |
| Melting Point | Melting Point Apparatus | A physical constant used for identification. As a solid compound, its typical melting range should be experimentally determined (literature or measured value, e.g., 120–135 °C), useful for batch-to-batch consistency comparison. |
| Infrared Spectroscopy (IR) Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare characteristic absorption peaks with reference standards (e.g., C=N thiazole ring ~1600 cm⁻¹, N–H stretch ~3300 cm⁻¹, S–CH₂ ~1200 cm⁻¹) for structural confirmation and authenticity verification. |
| Nuclear Magnetic Resonance (¹H/¹³C NMR) | Nuclear Magnetic Resonance Spectroscopy | Used for structural confirmation and qualitative impurity analysis, especially during new process development or impurity tracing. Structural integrity is verified via characteristic proton signals (e.g., –N(CH₃)₂, –CH₂–S–, –NH₂) and their chemical shifts. |
| Chloride Ions / Inorganic Anions | Ion Chromatography (IC) or Silver Nitrate Titration | If the synthesis involves halogenated intermediates (e.g., chloroethyl sulfide), residual chloride ions must be tested to ensure process cleanliness. |
| Particle Size Distribution (if solid powder) | Laser Diffraction or Microscopy | If used as a pharmaceutical raw material, particle size must be controlled to ensure dissolution and uniform mixing, particularly for spray-dried or crystalline products. |
Technical Specifications of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow powder or crystals |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Safety Information of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Industrial 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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