Methyl 5-bromo-2-chloropyridine-3-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 78686-79-0 |
| Product name | Methyl 5-bromo-2-chloropyridine-3-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 5-bromo-2-chloropyridine-3-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 5-bromo-2-chloropyridine-3-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 5-bromo-2-chloropyridine-3-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for antiviral drugs such as entecavir | Applied in chemical synthesis to construct heterocyclic scaffolds, including purine rings and quinolines |
| Pharmaceuticals | Synthetic raw material for anticancer drugs (e.g., kinase inhibitors) | Used to introduce functional groups via coupling reactions or nucleophilic substitution |
| Chemicals | Organic synthesis building block | Serves as a starting material in multistep syntheses to prepare more complex nicotinic acid derivatives |
Manufacturing Quality Control of Methyl 5-bromo-2-chloropyridine-3-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and peak area normalization. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, dichloromethane) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content in the sample. |
| Heavy Metals | ICP-OES | Multi-element detection after acid digestion; total heavy metals (Pb, Cd, Hg, As) reported as ppm against calibration standards. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| Bromide Content | Ion Chromatography | Separation of bromide anion on anion-exchange column with conductivity detection; quantified via external calibration. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator; measures free acid impurities from hydrolysis. |
| Appearance | Visual Inspection | Assessment of color and physical state (crystalline solid) against standard reference under controlled white light. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid using calibrated digital melting point instrument. |
| Residue on Ignition | Gravimetric Analysis | Ignition at 700-800 C followed by weighing of non-volatile residue; indicates inorganic ash content. |
| Particle Size Distribution | Laser Diffraction | Dry dispersion and measurement of particle size distribution using laser diffraction principle and Mie theory. |
Technical Specifications of Methyl 5-bromo-2-chloropyridine-3-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 5-bromo-2-chloropyridine-3-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 5-bromo-2-chloropyridine-3-carboxylate
Safety Information of Methyl 5-bromo-2-chloropyridine-3-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 5-bromo-2-chloropyridine-3-carboxylate
Industrial Methyl 5-bromo-2-chloropyridine-3-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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