2-Chloro-5-fluoronicotinonitrile Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 791644-48-9 |
| Product name | 2-Chloro-5-fluoronicotinonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Chloro-5-fluoronicotinonitrile
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Chloro-5-fluoronicotinonitrile Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Chloro-5-fluoronicotinonitrile
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing active pharmaceutical ingredients (APIs), including antitumor agents and kinase inhibitors | Constructs complex molecular frameworks via organic synthesis steps such as nucleophilic substitution and coupling reactions (e.g., Suzuki, Buchwald–Hartwig) |
| Agricultural Chemicals | Structural building block for synthesizing novel insecticides, herbicides, or fungicides | Introduces target pesticide molecules through functional group transformations, including nitrile conversion (e.g., hydrolysis to amides or carboxylic acids) and halogen substitution |
| Fine Chemicals | Building block for fluorinated heterocyclic compounds used in functional materials or electronic chemicals | Leverages multifunctionality for selective functionalization and participates in multistep synthetic routes to produce high-value fine chemicals |
Manufacturing Quality Control of 2-Chloro-5-fluoronicotinonitrile
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state (e.g., white to off-white crystalline powder), and check for clumping or visible foreign particles. |
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with that of the reference standard in the range of 4000–400 cm⁻¹; characteristic peaks should be consistent. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with an appropriate mobile phase (e.g., acetonitrile-water or buffer system) under gradient elution, detected by UV detector (around 254 nm), and calculate the main component content using external standard method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Same conditions as content determination; detect and quantify individual impurity peaks. Typically, each individual impurity ≤ 0.1%, total impurities ≤ 0.5%. |
| Water Content | Karl Fischer Titration | Use an automatic moisture analyzer with coulometric or volumetric Karl Fischer method to accurately determine water content; generally limited to ≤ 0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Follow ICH guidelines to detect organic solvents used during production (e.g., methanol, ethanol, ethyl acetate), using headspace injection and FID detection. |
| Melting Point | Melting Point Determination | Determine the melting temperature using a melting point apparatus or capillary tube method, and compare with literature values (e.g., reported approximately XX °C) to assess purity. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Method | Take a specified amount of sample, add sulfuric acid, then ignite at high temperature until constant weight. Weigh the residue; typically limited to ≤ 0.1%. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determine levels of heavy metals such as lead, cadmium, mercury, and arsenic; comply with pharmacopoeial or client specifications (e.g., ≤ 10 ppm). |
| Chloride Impurities | Ion Chromatography (IC) or Titration | Detect free chloride ions or other chloride-containing by-products to ensure reaction by-products are controlled within safe limits. |
Technical Specifications of 2-Chloro-5-fluoronicotinonitrile
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow crystalline solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 62.0 - 66.0 °C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Chloro-5-fluoronicotinonitrile
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Chloro-5-fluoronicotinonitrile
Safety Information of 2-Chloro-5-fluoronicotinonitrile
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-Chloro-5-fluoronicotinonitrile
Industrial 2-Chloro-5-fluoronicotinonitrile Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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