Methyl N-(tert-butoxycarbonyl)-L-threoninate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 79479-07-5 |
| Product name | Methyl N-(tert-butoxycarbonyl)-L-threoninate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl N-(tert-butoxycarbonyl)-L-threoninate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl N-(tert-butoxycarbonyl)-L-threoninate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl N-(tert-butoxycarbonyl)-L-threoninate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral building block for synthesizing peptide-based drugs and antibiotics (e.g., certain β-lactamase inhibitors) | Used as a protected threonine derivative in solid-phase or solution-phase peptide synthesis; deprotection of the BOC group enables coupling; the methyl ester group may undergo selective hydrolysis or directly participate in cyclization reactions |
| Organic Synthesis | Chiral auxiliary or chiral source in asymmetric synthesis for constructing complex molecules containing threonine motifs | Introduces chiral centers via stereoselective alkylation, reduction, or coupling reactions; leverages its C2 chirality to induce diastereoselectivity |
| Biochemical Research | Preparation of isotopically labeled (e.g., ¹³C/¹⁵N) threonine probes to study protein post-translational modification mechanisms | Serves as a starting material in stable isotope labeling syntheses; isotopic atoms are incorporated under mild conditions—such as catalytic hydrogenation or transesterification—while preserving chiral integrity |
Manufacturing Quality Control of Methyl N-(tert-butoxycarbonyl)-L-threoninate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (BOC-Threonine Methyl Ester Content) | HPLC with UV detection | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase, with quantification via UV detection. |
| Residual Solvents (e.g., methanol, dichloromethane) | GC-FID | Volatile organic impurities are separated by gas chromatography and detected by flame ionization. |
| Water Content | Karl Fischer Titration | Electrochemical titration measuring water via iodine-sulfur dioxide reaction in anhydrous methanol-based medium. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification after acid digestion, based on mass-to-charge ratio detection in plasma ionization. |
| Residual Inorganic Salts (e.g., NaCl, K2CO3) | Ion Chromatography | Anion/cation separation on ion-exchange column with conductivity detection. |
| Related Substances (impurity profiling) | HPLC with gradient UV | Detection and quantification of structurally related impurities using optimized reversed-phase gradient elution. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using sodium D-line light in solution at controlled temperature and concentration. |
| pH (1% w/v aqueous solution) | Potentiometric pH measurement | Hydrogen ion activity measured using calibrated glass electrode in aqueous suspension/solution. |
| Appearance (Color and Clarity) | Visual Inspection | Assessment against established standards for color (e.g., APHA) and absence of visible particulates or haze. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change under controlled heating rate. |
| Residue on Ignition | Gravimetric Analysis | Mass of non-volatile inorganic residue determined after high-temperature ashing and cooling in desiccator. |
Technical Specifications of Methyl N-(tert-butoxycarbonyl)-L-threoninate
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -20.2 to -18.8 deg (c=1, in methanol) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl N-(tert-butoxycarbonyl)-L-threoninate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl N-(tert-butoxycarbonyl)-L-threoninate
Safety Information of Methyl N-(tert-butoxycarbonyl)-L-threoninate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl N-(tert-butoxycarbonyl)-L-threoninate
Industrial Methyl N-(tert-butoxycarbonyl)-L-threoninate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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