(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 796096-64-5 |
| Product name | (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for synthesizing antipsychotic agents (e.g., aripiprazole analogues) and 5-HT1A receptor modulators | Used as a protected form of the (S)-piperazine fragment to introduce chiral piperazine structure in coupling reactions; followed by BOC deprotection, hydrolysis/aminolysis, and other steps to construct the target molecule core |
| Pharmaceutical R&D | Chiral building block for constructing candidate compound libraries containing 2-substituted piperazine scaffolds | Employed as a structural diversity module in solid-phase or solution-phase combinatorial synthesis, participating in multi-step functional group transformations including amidation, sulfonylation, and alkylation |
| Fine Chemicals | Precursor to chiral catalyst ligands | Derivatized to prepare chiral bidentate N,N-ligands for asymmetric hydrogenation or C–N coupling reactions (limited literature reports; potential application) |
Manufacturing Quality Control of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation of (S)- and (R)-enantiomers on a chiral stationary phase, with quantification based on peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, THF, ethyl acetate) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, with detection at sub-ppt levels. |
| Residual BOC Reagent (Di-tert-butyl dicarbonate) | GC-MS | Detection and quantification of unreacted or hydrolyzed BOC reagent by gas chromatography coupled with mass spectrometry. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Identification and quantification of process-related impurities and degradation products using stressed conditions (acid/base/oxidative/thermal). |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-state transition temperature range using calibrated capillary apparatus per USP <741>. |
| Optical Rotation | [α]D Measurement | Measurement of specific rotation at 589 nm (Na D-line) in solution to confirm chiral integrity and batch-to-batch consistency. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing to assess inorganic impurities per USP <281>. |
Technical Specifications of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | -25.0 to -29.0 deg (c=1, in methanol) |
| Melting Point | 78.0 to 82.0 °C |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
Safety Information of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
Industrial (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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