GMBS Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 80307-12-6 |
| Product name | GMBS |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for GMBS
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk GMBS Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of GMBS
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Chemical modification and crosslinking of biomacromolecules, such as proteins and peptides | In a pH 7.5–9.0 buffer system (e.g., PBS or carbonate buffer), the NHS ester group undergoes nucleophilic substitution with primary amines (e.g., lysine side chains or N-terminal amines) to form stable amide bonds, introducing maleimide functionality for subsequent thiol-specific conjugation |
| Antibody–Drug Conjugate (ADC) Development | Preparation of thiol-reactive linker intermediates to enable site-specific conjugation of antibodies to small-molecule toxins | MBSA is first coupled to antibody lysine residues via NHS ester chemistry to introduce maleimide groups; subsequently, it reacts with free thiols on toxins (generated by partial reduction) via Michael addition to form stable thioether bonds |
| Materials Science | Surface functionalization of nanoparticles, microspheres, and solid-phase carriers to confer thiol reactivity | In organic solvents (e.g., DMF or DMSO) or aqueous/organic mixed phases, MBSA reacts with amine-functionalized surfaces (e.g., amino-modified silica, amino magnetic beads, or NH₂-PEG-coated liposomes) to generate surface-bound maleimide groups, enabling subsequent conjugation of thiolated ligands (e.g., peptides or nucleic acids) |
| Diagnostics Reagents | Preparation of thiol-labeled fluorescent probes, enzyme-conjugated antibodies, and biosensor recognition elements | MBSA is reacted with amine-containing reporter molecules (e.g., FITC-NH₂ or HRP-NH₂) to yield maleimide-reporter conjugates, which are then coupled to target proteins or aptamers bearing free thiols to achieve oriented, controlled labeling |
Manufacturing Quality Control of GMBS
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Identity | FT-IR Spectroscopy | Confirmation via characteristic functional group absorptions (e.g., imide C=O at ~1700 cm⁻¹, NHS ester C=O at ~1800 and ~1750 cm⁻¹). |
| Residual Solvents (e.g., DCM, DMF, Acetonitrile) | GC-FID | Separation and quantification of volatile organic solvents using capillary GC with flame ionization detection, per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of water with iodine and sulfur dioxide in pyridine/methanol medium. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element trace metal quantification after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Acid Value | Acid-Base Titration | Neutralization of free carboxylic acid groups with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| NHS Ester Content | UV-Vis Spectrophotometry | Quantification via hydroxylamine-mediated cleavage to release hydroxamic acid, measured at ~520 nm after complexation with Fe³⁺. |
| Related Substances | HPLC-UV (with gradient elution) | Detection and quantification of structurally related impurities (e.g., hydrolyzed acid, maleimide dimer, NHS hydrolysis product) using validated stability-indicating method. |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic ash content by high-temperature incineration (500–600 °C) followed by precise weighing of residual residue. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory under controlled dispersion conditions. |
| Microbial Contamination | Membrane Filtration & Plate Count | Enumeration of aerobic mesophilic microorganisms following USP <61> using membrane filtration and incubation on soybean-casein digest agar. |
| pH of 1% Aqueous Solution | Potentiometric pH Measurement | Direct measurement using calibrated pH electrode in aqueous suspension (after brief sonication and equilibration), per USP <791>. |
Technical Specifications of GMBS
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 118-122°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of GMBS
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of GMBS
Packaging of GMBS
Industrial GMBS Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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