China Factory Direct
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| CAS number | 80522-42-5 |
| Product name | TRIISOPROPYLSILYL TRIFLUOROMETHANESULFONATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Organic Synthesis | Reagent for introducing silyl protecting groups, used to protect hydroxyl functional groups in alcohols and phenols | Reacted with alcohols or phenols under anhydrous conditions to form corresponding triisopropylsilyl (TIPS) ethers, enhancing selectivity in subsequent reactions |
| Medicinal Chemistry | Used in selective protection steps during the synthesis of complex natural products and pharmaceutical molecules | Temporarily masks sensitive hydroxyl groups in multistep syntheses to prevent side reactions; hydroxyl groups are regenerated via fluoride-mediated deprotection |
| Materials Science | Surface modification of silica-based materials to tune hydrophobicity or reactivity | Reacted with hydroxyl-containing silicon wafers or nanoparticles to form stable siloxane surface layers |
| Biochemistry | Protection of hydroxyl groups in carbohydrates or peptides to facilitate structural modification or labeling | Enables selective silylation of biomolecules under mild conditions, maintaining compatibility with other functional groups |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detection | Quantitative determination based on peak area comparison against certified reference standard using a non-polar capillary column. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) | Volatile organic impurities are vaporized in sealed vials and quantified by GC-FID or GC-MS relative to calibration standards. |
| Water Content | Karl Fischer Titration (Coulometric mode) | Electrochemical titration where iodine generated in situ reacts stoichiometrically with water; endpoint detected amperometrically. |
| Acidity (as H2SO4 equivalent) | Acid-Base Titration with NaOH | Neutralization of acidic impurities using standardized sodium hydroxide solution and potentiometric endpoint detection. |
| Chloride Impurity | Ion Chromatography (IC) with conductivity detection | Separation of anions on an ion-exchange column followed by quantitative detection via suppressed conductivity. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element trace metal quantification after acid digestion, using mass spectrometric detection with isotopic resolution. |
| Residual Catalyst (e.g., Pd) | ICP-OES | Quantitative elemental analysis after microwave-assisted acid digestion, using plasma-induced atomic emission. |
| Appearance | Visual Inspection | Assessment of liquid clarity and color against standard references under controlled lighting and against white background. |
| Density | Digital Density Meter (Oscillating U-tube principle) | Measurement of sample density at specified temperature based on resonant frequency shift of a vibrating U-shaped tube filled with sample. |
| Refractive Index | Digital Refractometer | Determination of refractive index at 20 degrees C using total internal reflection angle measurement of monochromatic light. |
| Volatility Loss (Loss on Drying) | Thermogravimetric Analysis (TGA) | Mass loss measured under nitrogen purge while heating from 25 to 150 degrees C; reports volatile content. |
| Organic Impurity Profile | GC-MS | Identification and semi-quantification of unknown volatile/semi-volatile impurities using retention time and electron ionization mass spectra matching. |
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.410–1.420 |
| Relative Density (20°C/25°C) | 1.22–1.24 g/cm³ |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Danger |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.