1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 808137-94-2 |
| Product name | 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Small-molecule kinase inhibitor intermediates | Used in the synthesis of candidate BTK (Bruton’s tyrosine kinase) inhibitors; for example, incorporating a pyrrolopyrimidine core during structural optimization to enhance target-binding affinity and metabolic stability |
| Pharmaceutical R&D | JAK/STAT signaling pathway modulator building blocks | Serve as key heterocyclic building blocks in multistep coupling reactions (e.g., Suzuki or Buchwald–Hartwig cross-coupling) to construct novel JAK inhibitor scaffolds with anti-inflammatory or antitumor activity |
Manufacturing Quality Control of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at characteristic wavelength based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities by separation on a C18 column and UV detection, comparing retention times and peak areas to qualified standards or threshold responses. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents using gas chromatography with flame ionization detection, calibrated against solvent reference solutions. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration where iodine reacts stoichiometrically with water in a controlled electrochemical or chemical system. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, As) after acid digestion by measuring metal ion mass-to-charge ratios with high sensitivity and multi-element capability. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and conductivity detection, calibrated with sodium chloride standards. |
| Sulfate Content | Ion Chromatography | Separates and quantifies sulfate ions using anion-exchange column and conductivity detection, calibrated with sodium sulfate standards. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C followed by precise weighing of the non-volatile residue. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity via thermal behavior. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light induced by chiral molecules in solution, confirming enantiomeric identity and purity. |
| Particle Size Distribution | Laser Diffraction | Analyzes particle size distribution by measuring angular variation in intensity of laser light scattered by dispersed particles in suspension or air. |
| Microbial Limits | Membrane Filtration | Detects and enumerates viable aerobic microorganisms by filtration, membrane transfer to nutrient agar, and colony counting after incubation. |
Technical Specifications of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
Safety Information of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
Industrial 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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