N-[(1,1-Dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-D-alanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 81306-93-6 |
| Product name | N-[(1,1-Dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-D-alanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 81306-93-6
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 81306-93-6 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 81306-93-6
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral amino acid protecting intermediate for peptide synthesis | Used as an Nα-dual protecting reagent for D-alanine residues in solid-phase peptide synthesis (SPPS) to construct therapeutic peptide sequences containing D-alanine |
| Pharmaceutical R&D | Chiral building block for drug synthesis | Provides configurationally stable D-alanine units for structural modification of candidate drug molecules (e.g., anticancer and antiviral agents), enabling coupling reactions after deprotection |
Manufacturing Quality Control of 81306-93-6
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210–220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantioselective separation on a chiral stationary phase, confirming D-configuration by retention time match with D-enantiomer reference. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., DMF, methanol, ethyl acetate) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, achieving sub-ppb detection limits. |
| Residual Chlorides | Ion Chromatography (IC) | Separation and conductivity detection of chloride ions in aqueous extract; quantified against NaCl calibration standards. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Stress testing (acid/base/oxidative/thermal/light) followed by HPLC-UV to identify and quantify structurally related impurities per ICH Q5A/Q3B. |
| Appearance & Color | Visual Inspection / APHA Color Scale | Comparison of dissolved sample solution (e.g., in methanol) against platinum-cobalt standards for color intensity and clarity assessment. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination via controlled heating; sharp melting range confirms crystallinity and absence of significant eutectics. |
| Residual Palladium | ICP-OES | Quantification of Pd from catalyst residues after microwave-assisted nitric/hydrochloric acid digestion, per ICH Q3D. |
| Loss on Drying (LOD) | Thermogravimetric Analysis (TGA) | Weight loss measurement upon controlled heating (e.g., 105 °C, 2 h) to determine volatile content including solvates and moisture. |
| pH (1% w/v aqueous suspension) | pH Meter | Electrochemical measurement of hydrogen ion activity in aqueous suspension, indicating acidic/basic impurities or hydrolytic instability. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersion using Mie theory to determine D10, D50, D90 values relevant to filtration and formulation handling. |
| Microbial Limits | Membrane Filtration / TSA/SDA | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 81306-93-6
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C to 132°C |
| Optical Rotation | -15.0° to -19.0° (c=1, in DMF) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 81306-93-6
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 81306-93-6 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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