tert-Butyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 81658-25-5 |
| Product name | tert-Butyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 81658-25-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 81658-25-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 81658-25-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Pharmaceutical Intermediates | Used as a chiral building block for synthesizing chiral drug molecules, particularly those containing a pyrrolidinone structure. |
| Pharmaceutical Industry | Peptide Synthesis | Applied in derivatization reactions via the side-chain hydroxymethyl group to synthesize structurally modified peptide drugs or protected amino acid derivatives. |
| Organic Synthesis | Chiral Ligands or Auxiliaries | Employed in asymmetric catalytic reactions via its chiral center or used as a chiral auxiliary to introduce chirality into target molecules. |
Manufacturing Quality Control of 81658-25-5
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-220 nm, comparing peak area to a reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., ethyl acetate, heptane, methanol) by headspace GC with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Optical Rotation | [alpha]D Measurement | Measures specific optical rotation at 20 °C using sodium D-line (589 nm) to confirm chiral integrity and enantiomeric excess. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, As, Hg, Co) after acid digestion using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-MS | Specific quantification of Pd catalyst residue post-coupling reactions using ICP-MS with isotope dilution or external calibration. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual tert-Butyl Alcohol | GC-FID | Detects residual t-BuOH from Boc deprotection or synthesis by direct injection GC-FID with internal standard. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid sample against white/black background under controlled lighting. |
| Loss on Drying | Gravimetric Analysis | Measures volatile content by weight loss after drying under vacuum at 40-50 °C for 2-3 hours. |
Technical Specifications of 81658-25-5
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Optical Rotation | +24.0 to +26.0° (c=1, in CHCl3) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 81658-25-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 81658-25-5
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Industrial 81658-25-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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