2-Amino-3-fluorobenzoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 825-22-9 |
| Product name | 2-Amino-3-fluorobenzoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Amino-3-fluorobenzoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Amino-3-fluorobenzoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Amino-3-fluorobenzoic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antitumor drug intermediates | Used as a key intermediate to construct the molecular scaffolds of quinazoline- or fluorobenzoic acid-derived compounds, participating in coupling or cyclization reactions |
| Pesticides | Synthesis of fluorinated insecticide or herbicide intermediates | Applied in the preparation of biologically active fluorinated aromatic heterocyclic compounds, introducing target molecules via amidation or substitution reactions |
| Dyes | Synthesis of organic pigments or fluorescent dyes | Participates in azo coupling reactions or serves as a functionalized aromatic acid component to enhance dye photostability and solubility |
| Fine Chemicals | Precursor for functional materials | Used to synthesize organic semiconductor materials with specialized optoelectronic properties or ligands for metal–organic frameworks (MOFs) |
Manufacturing Quality Control of 2-Amino-3-fluorobenzoic acid
| Maintenance Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe the color, crystal form, and whether the sample is caked. Determine the melting point range (literature value approximately 145–150°C) using a melting point apparatus to assess purity and crystallization state. |
| Content Determination (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 chromatographic column, with water-methanol or acetonitrile-buffer salt (e.g., phosphate) as the mobile phase, and a UV detector (254 nm) for detection. Quantify using an external standard method to accurately determine the content of the main component. |
| Related Substances (Impurity Profile) | HPLC (Gradient Elution) | Separate possible impurities such as raw materials, intermediates, and degradation products using a gradient elution program. Detect at 254 nm, calculate relative retention time and impurity content, complying with ICH Q3B requirements. |
| Fluorine Content | Ion Chromatography (IC) or Fluoride Ion Selective Electrode | Determine fluoride ion concentration by ion chromatography after alkaline fusion or hydrolysis of the sample, or use a fluoride ion selective electrode for potentiometric titration. Verify that the fluorine content matches the theoretical value (theoretical F% ≈ 16.8%). |
| Moisture Content | Karl Fischer Titration | Quantitatively determine trace moisture in the sample using Karl Fischer reagent through electrochemical or volumetric methods, controlling moisture ≤ 0.5% to ensure stability. |
| Solvent Residues | Gas Chromatography (GC) | Use headspace or direct injection, with DB-624 capillary column and FID detector to detect residual solvents such as ethanol, acetone, DMF, complying with ICH Q3C standards. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine heavy metal content (e.g., lead, cadmium, mercury, arsenic) after sample digestion using AAS or ICP-MS, ensuring compliance with pharmacopoeia limits (e.g., Pb ≤ 10 ppm). |
| pH Value (Aqueous Solution) | pH Meter Measurement | Prepare a 1% aqueous solution of the sample and measure the pH value using a calibrated pH meter (theoretical value ≈ 4.5–5.5), evaluating acidity/alkalinity and potential hydrolysis tendency. |
| Melting Point | Capillary Melting Point Apparatus | Precisely determine the melting point range and compare it with the literature value (145–150°C) to assess crystalline purity and presence of eutectic impurities. |
| Inorganic Impurities (e.g., Chlorides, Sulfates) | Colorimetry (Pharmacopoeia General Method) | Test for chlorides (white turbidity) by adding silver nitrate reagent to the aqueous solution, and test for sulfates (white precipitate) by adding barium chloride, complying with pharmacopoeia limit requirements. |
| Polymorphic Analysis (Optional) | X-ray Powder Diffraction (XRPD) | Used to confirm the consistency of the product's polymorphic form, avoiding the impact of multiple polymorphs on solubility and stability, suitable for high-end formulation raw materials. |
Technical Specifications of 2-Amino-3-fluorobenzoic acid
| Test Item | Specification |
|---|---|
| Appearance | Light brown crystalline solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 145–149 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Amino-3-fluorobenzoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Amino-3-fluorobenzoic acid
Packaging of 2-Amino-3-fluorobenzoic acid
Industrial 2-Amino-3-fluorobenzoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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