China Factory Direct
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| CAS number | 83255-86-1 |
| Product name | 7-bromo-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing kinase inhibitors (e.g., JAK and BTK inhibitors) | Prepared via nucleophilic substitution of 3-bromo-1H-pyrazolo[3,4-d]pyrimidine with ammonia or amine reagents |
| Pharmaceuticals | Construction of antitumor agents containing the pyrazolopyrimidine scaffold | Used as a key intermediate in multistep coupling, cyclization, or functional group transformation reactions |
| Chemical Research | Development of organic synthetic methodologies | Employed as an electrophilic reagent in transition metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) |
| Pharmaceuticals | Precursor for synthesizing selective protein kinase inhibitors | Amino group introduced via ammonolysis or amination, followed by further derivatization to construct the drug molecule |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at characteristic wavelength, comparing peak area to reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities by retention time separation and UV response relative to main peak. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents using gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration using iodine-based redox reaction specific to water. |
| Heavy Metals | ICP-MS | Determines trace metal contaminants (e.g., Pb, Cd, Ni) by plasma ionization and mass spectrometric detection. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Sulfate Impurity | Ion Chromatography | Separates and quantifies sulfate ions using anion-exchange column and conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content after high-temperature incineration and weighing of residual solids. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using controlled heating and visual observation. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light and against standard references. |
| Bulk Density | USP <616> Tap Density Method | Measures mass per unit volume after standardized tapping of a powder sample in a graduated cylinder. |
| Microbial Contamination | Membrane Filtration | Detects viable aerobic microorganisms by filtration, membrane transfer to culture media, and colony enumeration. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 245–249 °C |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.