N-Fmoc-N'-tosyl-L-arginine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 83792-47-6 |
| Product name | N-Fmoc-N'-tosyl-L-arginine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Fmoc-N'-tosyl-L-arginine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Fmoc-N'-tosyl-L-arginine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Fmoc-N'-tosyl-L-arginine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a protecting amino acid derivative in peptide synthesis to construct peptide chains containing arginine residues | Introduced into the arginine side chain during solid-phase peptide synthesis (SPPS) under the Fmoc strategy, where the α-amino group is protected by Fmoc and the guanidino group by tosyl (Tos) to suppress side reactions and enhance selectivity |
| Biochemical Research | Used to synthesize arginine-modified peptides with specific biological activity, such as protease inhibitors or cell-penetrating peptides | Fmoc deprotection is performed under mild basic conditions while retaining the Tos protecting group; subsequent Tos removal is achieved using strong acids (e.g., HF or TFMSA) to fully deprotect the arginine side chain |
| Organic Synthesis | Employed as a chiral building block in the construction of complex molecules | Leverages its dual protection to enable regio- and stereoselective control across multistep syntheses |
Manufacturing Quality Control of N-Fmoc-N'-tosyl-L-arginine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 260 nm. |
| Identity | FTIR Spectroscopy | Confirmation of molecular structure via characteristic functional group absorption bands in the mid-infrared region. |
| Chiral Purity | Chiral HPLC | Separation and quantification of enantiomers using a chiral stationary phase to confirm L-configuration dominance. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents (e.g., DMF, DCM, methanol) based on retention time and flame ionization response. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water via iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, based on atomic emission intensity. |
| Residual Tosyl Chloride | GC-MS | Identification and quantification of unreacted tosyl chloride impurity using mass spectral fragmentation patterns and retention time. |
| Residual Fmoc-Cl | HPLC-UV | Detection of residual N-Fmoc-chloride by reversed-phase HPLC with UV detection at 270 nm. |
| Related Substances | HPLC-DAD | Detection and quantification of structurally related impurities using diode array detection for spectral confirmation. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in dry powder form via light scattering pattern analysis. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid phase transition temperature range using controlled heating and visual observation. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms by filtration, membrane transfer to culture media, and colony counting. |
Technical Specifications of N-Fmoc-N'-tosyl-L-arginine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148~152°C |
| Optical Rotation | -7.0 to -5.0° (c=1, DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Fmoc-N'-tosyl-L-arginine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Fmoc-N'-tosyl-L-arginine
Packaging of N-Fmoc-N'-tosyl-L-arginine
Industrial N-Fmoc-N'-tosyl-L-arginine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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