6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 84163-77-9 |
| Product name | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the atypical antipsychotic paliperidone | Chemical synthesis process for paliperidone production |
| Research & Development | Chemical reference standard or analytical standard in drug development | Laboratory process for analytical method development and validation |
| Chemicals | Synthesis of other fine chemicals or complex organic molecules | Fluorinated aromatic heterocyclic building block in organic synthesis |
Manufacturing Quality Control of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Testing | Observe solid color, crystal form, and odor; determine melting point range (typically 80–120°C). Confirm compliance with pharmacopoeial or internal company standards to assess whether the material has absorbed moisture, degraded, or been contaminated. |
| Assay (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with acetonitrile-water (containing 0.1% formic acid or trifluoroacetic acid) as mobile phase. Detect with UV detector (λ = 220–254 nm). Quantify main component using external standard or area normalization method. Purity typically required to be ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC with Gradient Elution | Apply gradient elution to separate degradation products, unreacted starting materials, and by-products. Detection wavelength usually set at 220 nm. Total impurities generally controlled to ≤1.0% (individual impurity ≤0.5%), in compliance with ICH Q3B guidelines. |
| Residual Solvents | Gas Chromatography (GC) | Use DB-624 or HP-INNOWAX capillary column with FID detector to analyze residual organic solvents (e.g., DMF, acetonitrile, methanol, dichloromethane). Control levels within PDE limits according to ICH Q3C guidelines. |
| Moisture Content | Karl Fischer Titration | Determine trace moisture content using coulometric or volumetric Karl Fischer titration. Typically controlled to ≤0.5% (may be relaxed to 1.0% depending on application) to ensure stability and storage safety. |
| Melting Point | Capillary Melting Point Apparatus | Determine melting point range using a digital melting point instrument. Compare with literature values (e.g., reported ~98–102°C) to assess crystal form consistency and purity. |
| UV-Visible Absorption Spectroscopy (UV-Vis) | UV-Vis Spectrophotometer | Prepare solution in ethanol or methanol (~10 μg/mL), scan 200–400 nm range, and record characteristic absorption peaks (e.g., λmax ≈ 230 nm). Used for qualitative identification and concentration estimation. |
| Fluorine Content | Ion Chromatography (IC) or Oxygen Bomb Combustion + Ion-Selective Electrode | Convert sample to fluoride ions via oxygen bomb combustion, then quantify using ion chromatography or fluoride ion-selective electrode. Verify fluorine content matches theoretical value (theoretical F% ≈ 8.5%) for structural confirmation. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of heavy metals (e.g., lead, cadmium, mercury, arsenic) according to pharmacopoeial methods (e.g., USP <231>). Limit to ≤10 ppm to ensure product safety. |
| Crystal Form Identification (if applicable) | X-Ray Powder Diffraction (XRPD) | For compounds sensitive to polymorphism, compare XRPD patterns with reference standards to confirm crystal form consistency and avoid differences in solubility and bioavailability due to polymorphic variation. |
| Optical Rotation (if chiral center present) | Polarimeter | If the compound contains a chiral center (the piperidine ring in this structure is non-chiral; may apply to derivatives), measure specific optical rotation to verify optical purity. Not applicable for this structure due to absence of chiral centers. |
Technical Specifications of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 178-182°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
Safety Information of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
Industrial 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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