3'-CHLORO-5'-FLUOROACETOPHENONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 842140-52-7 |
| Product name | 3'-CHLORO-5'-FLUOROACETOPHENONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3'-CHLORO-5'-FLUOROACETOPHENONE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3'-CHLORO-5'-FLUOROACETOPHENONE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3'-CHLORO-5'-FLUOROACETOPHENONE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the antitumor drug BMS-986142 (a BTK inhibitor) | Constructs the quinazolinone core structure via multi-step reactions including reductive amination and cyclization |
| Pharmaceuticals | Aryl ketone fragment in the synthesis of JAK2 inhibitor candidates | Acts as an electrophilic component in Suzuki coupling or reductive amination reactions |
| Agrochemicals | Fluorinated and chlorinated aryl ketone structural motif in novel fungicide molecular design | Used to build active molecular scaffolds with enhanced lipophilicity and target-binding affinity |
Manufacturing Quality Control of 3'-CHLORO-5'-FLUOROACETOPHENONE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., isomers, dehalogenated analogs) using gradient HPLC-UV with suitable column and mobile phase. |
| Residual Solvents | GC-FID | Identifies and quantifies residual solvents (e.g., acetone, dichloromethane) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generated electrochemically in presence of SO2 and base. |
| Chlorine Content | Oxygen Flask Combustion followed by Ion Chromatography | Converts organic chlorine to chloride ion by combustion in oxygen, then quantifies Cl- using ion chromatography with conductivity detection. |
| Fluorine Content | Pyrohydrolysis followed by Ion Chromatography | Releases fluorine as fluoride ion via high-temperature hydrolysis with steam, then quantifies F- using ion chromatography with conductivity detection. |
| Heavy Metals (Pb, Cd, Hg, Cr, As) | ICP-MS | Digests sample in acid mixture, then detects and quantifies trace heavy metals by inductively coupled plasma mass spectrometry. |
| Acid Value | Acid-Base Titration | Measures acidic impurities (e.g., carboxylic acids) by titration with standardized KOH solution using phenolphthalein indicator. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity via thermal behavior. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of neat substance under controlled lighting against established reference standards. |
| Particle Size Distribution | Laser Diffraction | Measures size distribution of solid particles in suspension using angular scattering pattern of laser beam. |
| Residue on Ignition | Gravimetric Analysis | Quantifies non-volatile inorganic residue after high-temperature ashing (700-800 C) followed by weighing of crucible residue. |
Technical Specifications of 3'-CHLORO-5'-FLUOROACETOPHENONE
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3'-CHLORO-5'-FLUOROACETOPHENONE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3'-CHLORO-5'-FLUOROACETOPHENONE
Safety Information of 3'-CHLORO-5'-FLUOROACETOPHENONE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3'-CHLORO-5'-FLUOROACETOPHENONE
Industrial 3'-CHLORO-5'-FLUOROACETOPHENONE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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