(S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 84348-38-9 |
| Product name | (S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 84348-38-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 84348-38-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 84348-38-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Serves as a synthetic intermediate for preparing proline-containing drug molecules, including antiviral agents, anticancer agents, and peptide-based therapeutics | Introduced as a BOC-protected methylene-proline unit into target peptide chains via solid-phase or liquid-phase peptide synthesis (SPPS/LPPS) |
| Peptide Chemistry | Used to synthesize non-natural amino acid-modified peptides featuring cyclic or rigid structures | Incorporated as a specialized amino acid residue during peptide chain elongation to enhance metabolic stability or conformational constraint |
| Organic Synthesis | Serves as a chiral building block for constructing complex heterocyclic compounds or natural product analogs | Undergoes selective deprotection and coupling reactions leveraging its BOC-protected secondary amine and carboxylic acid functional groups |
Manufacturing Quality Control of 84348-38-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification via retention time matching and threshold-based reporting. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., ethyl acetate, toluene) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation and stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni) after acid digestion using inductively coupled plasma mass spectrometry for ultra-trace detection. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Optical Rotation | [alpha]D Measurement | Measures specific optical rotation using sodium D-line light source to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Residue on Ignition | Gravimetric Analysis | Quantifies inorganic ash content by high-temperature incineration followed by precise weighing of residual residue. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution in dry or dispersed state using Mie scattering theory and laser diffraction principle. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Determines pH of 1% w/v suspension in water using calibrated glass electrode and pH meter. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic microorganisms and detects specified pathogens (e.g., E. coli) via membrane filtration followed by agar culture and colony enumeration. |
Technical Specifications of 84348-38-9
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -55.3 to -42.2 deg (c=1, in DMF) |
| Melting Point | 145 to 155 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 84348-38-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 84348-38-9
Packaging of 84348-38-9
Industrial 84348-38-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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