4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 84905-80-6 |
| Product name | 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for small-molecule targeted antitumor agents, used in the synthesis of EGFR and HER2 inhibitors (e.g., lapatinib analogues) | Aryl/heteroaryl substituents are introduced via palladium-catalyzed cross-coupling reactions (e.g., Suzuki or Heck reactions) under inert atmosphere; subsequent steps—including aminolysis and cyclization—construct the final molecular scaffold |
| Pharmaceuticals | Key intermediate for JAK kinase inhibitors | Nucleophilic substitution with specific amine compounds under basic conditions yields aminopyrrolopyrimidine derivatives, followed by purification and salt-form screening to obtain the active pharmaceutical ingredient |
Manufacturing Quality Control of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally similar impurities by gradient HPLC separation and UV detection relative to the main peak. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents using gas chromatography with flame ionization detection against calibration standards. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration using iodine generated electrochemically in a methanol-based reagent. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni) after acid digestion by inductively coupled plasma mass spectrometry. |
| Chloride Ion Impurity | Ion Chromatography | Separates and detects chloride anions using suppressed conductivity detection after aqueous eluent separation. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using controlled heating and visual observation. |
| Loss on Drying | Gravimetric Analysis | Measures mass loss after drying under specified vacuum/temperature conditions to assess volatile content. |
| Residue on Ignition | Sulfated Ash Method | Quantifies non-volatile inorganic residue after high-temperature combustion in presence of sulfuric acid. |
| Particle Size Distribution | Laser Diffraction | Measures size distribution of solid particles in suspension using angular scattering pattern of laser light. |
| Specific Optical Rotation | Polarimetry | Determines chiral purity by measuring rotation angle of plane-polarized light passing through solution. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Measures hydrogen ion activity in saturated aqueous suspension using calibrated glass electrode and pH meter. |
Technical Specifications of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 198–202°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
Safety Information of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE
Industrial 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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