Methyl 3-amino-4-methylthiophene-2-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 85006-31-1 |
| Product name | Methyl 3-amino-4-methylthiophene-2-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 3-amino-4-methylthiophene-2-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 3-amino-4-methylthiophene-2-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 3-amino-4-methylthiophene-2-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of antiviral drugs such as dolutegravir | Multi-step organic synthesis |
| Chemicals | Organic synthesis feedstock for constructing complex thiophene derivatives | Condensation and substitution reactions |
| Agrochemicals | Intermediate in the synthesis of bioactive thiophene-containing agrochemicals | Modification of heterocyclic compounds |
Manufacturing Quality Control of Methyl 3-amino-4-methylthiophene-2-carboxylate
| Test Item | Common Test Methods | Method Summary |
|---|---|---|
| Appearance | Visual Inspection / Microscopic Examination | Inspect the sample's color, physical state (e.g., white to off-white crystalline powder), and presence of foreign particles by naked eye or microscope to determine compliance with quality specifications. |
| Identification | Infrared Spectroscopy (IR) Proton Nuclear Magnetic Resonance (¹H NMR) HPLC Retention Time Comparison |
- IR: Record the infrared absorption spectrum and compare characteristic functional group peaks (e.g., ester carbonyl, amino group, thiophene ring) with a reference spectrum. - ¹H NMR: Analyze proton chemical shifts and coupling constants to confirm molecular structure. - HPLC: The retention time of the main peak of the sample should match that of the reference standard under identical chromatographic conditions. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with methanol-water or acetonitrile-buffer salt as mobile phase. Detect using a UV detector (typically 210–260 nm) and calculate the active ingredient content by external standard method. Acceptance criteria are typically ≥98.0%. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Apply a gradient elution program to separate the main component from potential impurities (e.g., starting materials, intermediates, degradation products). Control individual and total impurity levels using area normalization or a correction factor-based parent substance self-dilution method (e.g., individual impurity ≤0.5%, total impurities ≤1.0%). |
| Water Content | Karl Fischer Titration | Quantify water content based on the stoichiometric reaction of iodine and sulfur dioxide with water in the presence of pyridine/imidazole. Water content must be within specified limits (e.g., ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with a polar capillary column (e.g., DB-624) and FID detection to determine residual organic solvents (e.g., methanol, dichloromethane, toluene) from synthesis. Results must comply with ICH Q3C guidelines. |
| Melting Point | Capillary Melting Point Method | Pack sample into a capillary tube and heat gradually in a melting point apparatus. Record the temperature range from initial melting to complete melting and compare with literature values (e.g., approximately 140–144°C) to assess purity. |
| pH (if dissolved in solution) | pH Meter Method | Dissolve the sample in water to a defined concentration (e.g., 1%), then measure pH using a calibrated pH meter to evaluate whether acidity or alkalinity meets requirements. |
Technical Specifications of Methyl 3-amino-4-methylthiophene-2-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 3-amino-4-methylthiophene-2-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 3-amino-4-methylthiophene-2-carboxylate
Safety Information of Methyl 3-amino-4-methylthiophene-2-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 3-amino-4-methylthiophene-2-carboxylate
Industrial Methyl 3-amino-4-methylthiophene-2-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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