4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 85547-56-4 |
| Product name | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 85547-56-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 85547-56-4 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 85547-56-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for antimalarial drugs | Used as a 4-aminoquinoline antimalarial agent in the treatment and prevention of malaria, commonly administered in combination with artesunate |
| Pharmaceuticals | Reference standard for drug development | Applied in pharmacodynamic, pharmacokinetic, and safety evaluation studies of antimalarial drugs |
Manufacturing Quality Control of 85547-56-4
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | By comparing the infrared absorption spectra of the test sample with that of the reference standard, confirm its chemical structural characteristics, in accordance with pharmacopoeia standards. |
| High-Performance Liquid Chromatography (HPLC) | Compare retention time with reference substance to confirm the presence of main component; commonly used for qualitative identification and content determination in combination. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Using a C18 chromatographic column, with methanol-buffer solution (e.g., phosphate buffer) as the mobile phase, and UV detector at 254 nm for detection. Content is calculated by external standard method, complying with the requirements of the Chinese Pharmacopoeia. |
| Non-aqueous Titration | In acetic acid medium, titrate with perchloric acid titrant, using crystal violet as the indicator, suitable for content determination of raw materials. | |
| Related Substances | High-Performance Liquid Chromatography (HPLC) | Using gradient or isocratic elution, detect impurity peak area, calculate total impurity content by external standard method or area normalization method, limit usually ≤2.0%. |
| Dissolution | UV-Visible Spectrophotometry (UV-Vis) | Using paddle or basket method, simulating gastrointestinal environment, measure the amount of piperaquine phosphate released from the dosage form within specified time, applicable to tablets or capsules. |
| Residual Solvents | Gas Chromatography (GC) | Using capillary column and FID detector, according to the general rule for residual solvents in the Chinese Pharmacopoeia (0861), detect residues of organic solvents such as ethanol, acetone, dichloromethane, etc. |
| Moisture | Karl Fischer Titration | Determine trace moisture content using coulometric or volumetric methods, controlling moisture content within the specified limit (e.g., ≤3.0%). |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or ICP-MS | Determine heavy metals such as lead, cadmium, arsenic, mercury after sample digestion, in compliance with pharmacopoeia limits (e.g., ≤10 ppm). |
| Particle Size Distribution (Dosage Form) | Laser Diffraction | Used for oral suspensions or sustained-release formulations, controlling particle size to ensure consistency in dissolution and bioavailability. |
| Microbial Limit | Plate Count Method / MPN Method | Detect total aerobic bacteria, mold and yeast, Escherichia coli, etc., in compliance with microbial limit standards for non-sterile pharmaceuticals. |
| Abnormal Toxicity (Dosage Form) | Mice Test Method | Administer the test sample to mice as per pharmacopoeia regulations, observe for 72 hours; no death or abnormal reactions indicate compliance. |
Technical Specifications of 85547-56-4
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 85547-56-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 85547-56-4
Industrial 85547-56-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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