3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 858643-92-2 |
| Product name | 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate for constructing piperidine-containing drug molecules | Used as a BOC-protected acetylpiperidine unit in multistep synthesis, participating in coupling, reduction, or cyclization reactions |
| Medicinal Chemistry | Synthesis of candidate compounds targeting GPCRs, neurotransmitter receptors, etc. | Incorporated into the target molecular scaffold via deprotection and functional group transformations |
| Organic Synthesis | Chiral building block or structural directing unit for constructing complex nitrogen-containing heterocyclic systems | Applied in asymmetric synthesis or regioselective modification leveraging its stereocenter and reactive sites |
Manufacturing Quality Control of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV/DAD | Separation and detection of structurally related impurities (e.g., deprotected amine, hydrolysis products) using gradient HPLC with diode-array detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common solvents (e.g., THF, ethyl acetate, methanol) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample water. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, achieving sub-pptr detection limits. |
| Residual Palladium | ICP-MS | Specific quantification of Pd from catalytic hydrogenation steps, following microwave-assisted acid digestion. |
| Optical Rotation | [α]D | Measurement of specific rotation using a digital polarimeter at 20 °C and sodium D-line (589 nm) to confirm chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change under controlled heating rate (e.g., 1 °C/min). |
| Residual Chloride | Ion Chromatography (IC) | Quantitative separation and conductivity detection of chloride ions after aqueous extraction and filtration. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder size distribution based on angular scattering intensity of laser light. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined saturated aqueous suspension (e.g., 1% w/v) to assess acidic/basic degradation propensity. |
Technical Specifications of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 65–69°C |
| Identification (NMR) | Conforms to reference spectrum |
| Optical Rotation | +1.0° to +3.0° (c=1, in CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Safety Information of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Industrial 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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