Fmoc-S-acetamidomethyl-L-cysteine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 86060-81-3 |
| Product name | Fmoc-S-acetamidomethyl-L-cysteine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-S-acetamidomethyl-L-cysteine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-S-acetamidomethyl-L-cysteine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-S-acetamidomethyl-L-cysteine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Side-chain protecting reagent for cysteine residues in solid-phase peptide synthesis (SPPS) | In Fmoc-based synthesis, selectively protects the cysteine thiol (–SH) to form a stable thioether bond; the Fmoc amino-protecting group is removed under mild basic conditions (e.g., piperidine/DMF), while the acetamidomethyl (Acm) side-chain protecting group remains intact and can be subsequently cleaved selectively using iodine or silver salts to enable disulfide bond formation |
| Pharmaceutical R&D | Key building block for synthesizing cysteine-containing therapeutic peptides (e.g., insulin analogs, GLP-1 receptor agonists, antimicrobial peptides) | Used directly in coupling steps on automated peptide synthesizers as an enantiomerically pure Fmoc-Cys(Acm)-OH derivative, ensuring stereochemical integrity and orthogonality of side-chain protection |
| Biochemical Research | Cysteine-specific protecting tool for site-specific protein modification, disulfide bond engineering, and structure–function relationship studies | Provides thiol masking during multi-step synthesis or semisynthesis to prevent oxidation or side reactions, supporting controlled folding and functional characterization |
Manufacturing Quality Control of Fmoc-S-acetamidomethyl-L-cysteine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and form (typically white to off-white crystalline powder) for any foreign particles or agglomeration. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Utilize a reversed-phase C18 column with a UV detector (~265 nm or 220 nm); determine main peak purity by area normalization or external standard method, requiring ≥98.0%. |
| Specific Rotation | Optical Rotatory Power Measurement | Measure specific rotation [α]D²⁵ in a specified solvent (e.g., DMF or water/acetonitrile mixture) to verify consistency of chiral configuration (L-form). |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting temperature range of the sample and compare with the standard value (literature value ~130–135°C) to assess crystal form and purity. |
| Water Content | Karl Fischer Titration | Measure water content in the sample using coulometric or volumetric methods; generally require ≤1.0% to avoid affecting stability and reactivity. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection GC to detect organic solvents potentially residual from synthesis or purification (e.g., DCM, DMF, ethyl acetate, etc.). |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | According to pharmacopoeial methods (e.g., USP <231> or ICH Q3D), detect total heavy metals such as Pb, As, Cd, Hg; typically require ≤20 ppm. |
| S-Acm Protecting Group Integrity | HPLC or Mass Spectrometry Coupling (LC-MS) | Confirm the integrity of the S-Acm group via retention time and molecular ion peak (molecular weight should be C₂₅H₂₄N₂O₅S, theoretical value 464.53 g/mol), ensuring no deprotection or side reactions occurred. |
| Free Thiol Impurities | Ellman’s Reagent Method or HPLC | If S-Acm protection is incomplete, free thiols can react with DTNB to produce a colored complex measurable at 412 nm; alternatively, detect related impurity peaks via HPLC separation. |
| Related Substances / Impurities | Gradient Elution HPLC | Use a gradient elution program to separate potential process-related impurities (e.g., deprotected products, dimers, oxidation products); single impurity ≤0.5%, total impurities ≤1.0%. |
Technical Specifications of Fmoc-S-acetamidomethyl-L-cysteine
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -36.0 to -32.0 deg (c=1, in DMF) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-S-acetamidomethyl-L-cysteine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-S-acetamidomethyl-L-cysteine
Safety Information of Fmoc-S-acetamidomethyl-L-cysteine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-S-acetamidomethyl-L-cysteine
Industrial Fmoc-S-acetamidomethyl-L-cysteine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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