Fmoc-L-Aspartic acid-1-benzyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 86060-83-5 |
| Product name | Fmoc-L-Aspartic acid-1-benzyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-L-Aspartic acid-1-benzyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-L-Aspartic acid-1-benzyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-L-Aspartic acid-1-benzyl ester
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Side-chain protecting reagent for aspartic acid residues in solid-phase peptide synthesis (SPPS) | Used in Fmoc-based SPPS to incorporate aspartic acid residues protected with a benzyl (Bn) ester; the Fmoc group protects the α-amino group, while the benzyl ester protects the β-carboxyl group, enabling selective deprotection and coupling |
| Pharmaceutical R&D | Key building block for synthesizing therapeutic peptides containing aspartic acid sequences (e.g., hormone analogs, antimicrobial peptides, targeting peptides) | After Fmoc removal with piperidine on resin-bound growing peptide chains, coupled with the next activated Fmoc-amino acid; benzyl ester protecting groups are cleaved upon completion of synthesis using HBr/trifluoroacetic acid or catalytic hydrogenolysis |
| Biochemical Research | Preparation of site-specific aspartic acid probes labeled with isotopes or fluorescent tags | Enables selective derivatization at the side-chain benzyl ester site (e.g., hydrolysis followed by conjugation with fluorescent dyes), followed by hydrogenolysis to yield side-chain functionalized aspartic acid derivatives |
Manufacturing Quality Control of Fmoc-L-Aspartic acid-1-benzyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by UV absorbance at 268 nm using reverse-phase C18 column and gradient elution with aqueous buffer/acetonitrile. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., Fmoc-Asp-OH, di-Fmoc-Asp-OBn, hydrolysis/degradation products) using validated HPLC method. |
| Residual Solvents | GC-FID | Measures residual solvents (e.g., DMF, DCM, methanol, toluene) by gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generated electrochemically in pyridine/methanol-based reagent. |
| Optical Rotation | [alpha]D Measurement | Measures specific optical rotation at 589 nm (Na D-line) in solution to confirm chiral integrity and absence of racemization. |
| Heavy Metals | ICP-OES | Quantifies total heavy metals (Pb, Cd, Ni, Cu, Fe) after acid digestion by inductively coupled plasma optical emission spectrometry. |
| Residual Palladium | ICP-MS | Detects trace palladium (from Pd-catalyzed deprotection steps) using inductively coupled plasma mass spectrometry for high sensitivity. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Loss on Drying | Gravimetric Analysis | Measures volatile content by weight loss after drying under controlled vacuum and temperature (e.g., 60 C, 3 h). |
| Residual Benzyl Alcohol | GC-FID | Quantifies benzyl alcohol (a potential degradation product) by gas chromatography with flame ionization detection. |
| Particle Size Distribution | Laser Diffraction | Determines dry powder particle size distribution using Mie scattering theory with automated dispersion. |
| Microbial Contamination | Membrane Filtration | Detects aerobic microorganisms via filtration, membrane transfer to soybean-casein digest agar, and incubation per USP <61>. |
Technical Specifications of Fmoc-L-Aspartic acid-1-benzyl ester
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +10.0 to +14.0 deg (c=1, DMF) |
| Melting Point | 85 to 89 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-L-Aspartic acid-1-benzyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-L-Aspartic acid-1-benzyl ester
Safety Information of Fmoc-L-Aspartic acid-1-benzyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-L-Aspartic acid-1-benzyl ester
Industrial Fmoc-L-Aspartic acid-1-benzyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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