D-(+)-(2-Chlorophenyl)glycine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 86169-24-6 |
| Product name | D-(+)-(2-Chlorophenyl)glycine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for D-(+)-(2-Chlorophenyl)glycine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk D-(+)-(2-Chlorophenyl)glycine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of D-(+)-(2-Chlorophenyl)glycine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Serves as a key chiral intermediate in the synthesis of clopidogrel, a platelet aggregation inhibitor (antithrombotic agent). | Chiral synthesis or resolution process to construct chiral centers in drug molecules. |
| Pharmaceutical Industry | Used in the synthesis of thienopyridine-derived pharmaceuticals. | Chemical synthesis reaction involving functional group transformation of amino and carboxyl groups for structural modification. |
| Chemical Industry | Acts as a chiral building block for enantioselective synthesis of other fine chemicals. | Asymmetric synthesis process leveraging its chiral structure to induce formation of products with specific configuration. |
| Research Reagents | Serves as a reference standard in medicinal chemistry research and chiral drug analysis. | Laboratory analytical testing process, e.g., chromatographic reference standard. |
Manufacturing Quality Control of D-(+)-(2-Chlorophenyl)glycine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Characteristics | Visual Inspection, Physical Property Measurement | Observe sample color, crystal form, solubility, etc. Typically a white to off-white crystalline powder with no visible foreign particles. |
| Identification | Infrared Spectroscopy (IR) | Confirm characteristic functional groups (e.g., carboxyl, amino, phenyl ring, C-Cl bond) by comparing the infrared spectrum with that of a reference standard. |
| High-Performance Liquid Chromatography (HPLC) | Qualitative identification based on retention time matching that of the reference standard, often coupled with a UV detector. | |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Analyze hydrogen/carbon chemical shifts to confirm molecular structure, particularly useful for distinguishing enantiomers (D-configuration). | |
| Assay (Content Determination) | High-Performance Liquid Chromatography (HPLC) | Use reverse-phase C18 column with aqueous-methanol or aqueous-acetonitrile buffer mobile phase; quantification by external or internal standard method at detection wavelength 210–254 nm. |
| Titration (Acid-Base Titration) | Utilize glycine’s amphoteric properties by titrating the carboxyl group with standard NaOH solution; suitable for approximate content determination with lower precision. | |
| Specific Rotation (Optical Purity) | Polarimetry | Prepare a solution of known concentration in water and measure [α]D²⁵ using a polarimeter; compare with standard value (e.g., +XX°) to confirm D-configuration purity. |
| Impurity Detection (Organic Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution to detect related impurities (e.g., L-enantiomer, unreacted starting materials, degradation products); calculate impurity content as percentage of peak area. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with capillary columns such as DB-624 to detect residual solvents (e.g., ethanol, acetone, DMF); comply with ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Precisely determine trace water content in the sample; suitable for active pharmaceutical ingredient moisture control, in compliance with pharmacopoeial specifications (e.g., ≤0.5%). |
| Chloride Ion Content | Ionic Chromatography (IC) or Silver Nitrate Titration | Ion chromatography directly measures chloride ion concentration; silver nitrate titration detects chloride via precipitation of AgCl, suitable for inorganic chloride impurity control. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect heavy metal residues such as lead, cadmium, mercury, and arsenic; comply with pharmacopoeial limits (e.g., ≤10 ppm). |
| Microbial Limits | Microbial Enumeration and Control Organism Testing | Perform tests according to pharmacopoeial methods for aerobic microbial count, mold and yeast count, and detection of Escherichia coli; applicable to non-sterile API uses. |
| Crystal Form Analysis (Optional) | X-ray Powder Diffraction (XRPD) | Confirm crystal structure matches the reference polymorph to avoid potential impacts on solubility and stability due to polymorphic differences. |
Technical Specifications of D-(+)-(2-Chlorophenyl)glycine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 142-146°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | +12.0° to +14.0° (c=1, in 1M HCl) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of D-(+)-(2-Chlorophenyl)glycine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of D-(+)-(2-Chlorophenyl)glycine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of D-(+)-(2-Chlorophenyl)glycine
Industrial D-(+)-(2-Chlorophenyl)glycine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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